@article{oai:nagasaki-u.repo.nii.ac.jp:00027489,
 author = {Matsui, Kohsuke and Takahashi, Kensuke and Tashiro, Masato and Tanaka, Takeshi and Izumikawa, Koichi and Miura, Takashi and Eishi, Kiyoyuki and Furumoto, Akitsugu and Ariyoshi, Koya},
 issue = {1},
 journal = {BMC Infectious Diseases},
 month = {Jun},
 note = {Background: It is challenging to diagnose infected aneurysm in the early phase. This study aimed to describe the clinical and microbiological characteristics of infected aneurysm, and to elucidate the difculties in diagnosing the disease.
Methods: Forty-one cases of infected aneurysm were diagnosed in Nagasaki University Hospital from 2005 to 2019. Information on clinical and microbiological characteristics, radiological fndings, duration of onset, and type of initial computed tomography (CT) imaging conditions were collected. Factors related to diagnostic delay were analyzed by Fisher’s exact test for categorical variables or by the Wilcoxon rank-sum test for continuous variables.
Results: Pathogens were identifed in 34 of 41 cases; the pathogens were Gram-positive cocci in 16 cases, Gram-negative rods in 13 cases, and others in fve cases. Clinical characteristics did not difer in accordance with the identifed bacteria. At the time of admission, 16 patients were given diferent initial diagnoses, of which acute pyelonephritis (n=5) was the most frequent. Compared with the 22 patients with an accurate initial diagnosis, the 19 initially misdiagnosed patients were more likely to have been examined by plain CT. The sensitivities of plain CT and contrastenhanced CT were 38.1% and 80.0%, respectively.
Conclusions: In cases of infected aneurysm, diagnostic delay is attributed to non-specifc symptoms and the low sensitivity of plain CT. Clinical characteristics of infected aneurysm mimic various diseases. Contrast-enhanced CT should be considered if infected aneurysm is suspected., BMC Infectious Diseases, 22 (1), art. no. 585; 2022},
 title = {Clinical and microbiological characteristics and challenges in diagnosing infected aneurysm: a retrospective observational study from a single center in Japan},
 volume = {22},
 year = {2022}
}