{"created":"2023-05-15T16:49:55.760189+00:00","id":27585,"links":{},"metadata":{"_buckets":{"deposit":"348b6717-3ff5-400a-8947-3be51be71cc8"},"_deposit":{"created_by":6,"id":"27585","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"27585"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00027585","sets":["25:26"]},"author_link":["122677","122673","122669","122678","122667","122674","122668","122672","122680","122670","122675","122676","122679","122671"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-07-22","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"15","bibliographicPageStart":"3577","bibliographicVolumeNumber":"14","bibliographic_titles":[{"bibliographic_title":"Cancers"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Thyroid follicular-patterned tumors (TFTs) showing nodule-in-nodule (NN) appearance with poorly differentiated component (PDc) but neither invasion nor metastasis are diagnosed as benign nodules. Although PDc exhibits histologically aggressive features relative to the outer nodule (Out-N), its pathological significance remains unclear. TP53 binding protein-1 (53BP1) is a DNA damage response (DDR) molecule that rapidly localizes at DNA double-strand breaks. Using dualcolor immunofluorescence with Ki-67, the profile of 53BP1 expression is shown to be significantly altered during diverse tumorigenesis. In this study, we aimed to elucidate the malignant potential of PDc at the molecular level. We analyzed the profile of 53BP1 expression and NRAS codon 61 and TERT-promoter (TERT-p) mutations in 16 cases of TFTs showing NN with PDc compared to 30 adenomatous goiters, 31 follicular adenomas, 15 minimally invasive follicular carcinomas (FCs), and 11 widely invasive FC cases. Our results revealed that the expression level of abnormal type 53BP1 and incidence of NRAS and TERT-p mutations in PDc were comparable to FCs, suggesting a malignant potential. Because co-expression of 53BP1 and Ki-67 can be an indicator of altered DDR, the development of PDc in NN may be associated with DDR impairments after harboring NRAS and TERT-p mutations.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Cancers, 14(15), art. no. 3577; 2022","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3390/cancers14153577","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2072-6694","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ueda, Mayu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuda, Katsuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kurohama, Hirokazu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mussazhanova, Zhanna"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sailaubekova, Yerkezhan"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kondo, Hisayoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimizu, Tomoki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takada, Nami"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuoka, Yuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Otsubo, Chieko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Shinya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamashita, Hiroyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawakami, Atsushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakashima, Masahiro"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-09-13"}],"displaytype":"detail","filename":"C14_3577.pdf","filesize":[{"value":"4.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"C14_3577.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/27585/files/C14_3577.pdf"},"version_id":"0a13faec-cc4a-4599-b165-d5b53c517249"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"thyroid","subitem_subject_scheme":"Other"},{"subitem_subject":"nodule-in-nodule","subitem_subject_scheme":"Other"},{"subitem_subject":"poorly differentiated component","subitem_subject_scheme":"Other"},{"subitem_subject":"53BP1","subitem_subject_scheme":"Other"},{"subitem_subject":"NRAS","subitem_subject_scheme":"Other"},{"subitem_subject":"genomic instability","subitem_subject_scheme":"Other"},{"subitem_subject":"immunofluorescence","subitem_subject_scheme":"Other"},{"subitem_subject":"Ki-67","subitem_subject_scheme":"Other"},{"subitem_subject":"DNA damage response","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Molecular Pathological Characteristics of Thyroid Follicular-Patterned Tumors Showing Nodule-in-Nodule Appearance with Poorly Differentiated Component","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Molecular Pathological Characteristics of Thyroid Follicular-Patterned Tumors Showing Nodule-in-Nodule Appearance with Poorly Differentiated Component"}]},"item_type_id":"2","owner":"6","path":["26"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-09-13"},"publish_date":"2022-09-13","publish_status":"0","recid":"27585","relation_version_is_last":true,"title":["Molecular Pathological Characteristics of Thyroid Follicular-Patterned Tumors Showing Nodule-in-Nodule Appearance with Poorly Differentiated Component"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-05-15T19:37:41.529929+00:00"}