@phdthesis{oai:nagasaki-u.repo.nii.ac.jp:00027618,
 author = {Hoang, Thi Thu Trang},
 month = {Sep},
 note = {Neuropsychiatric systemic lupus erythematosus (NPSLE) varies in presentation and is one of the leading causes of morbidity and mortality among patients with SLE. This study determined the most critical serum biomarkers for the development of NPSLE as they may have clinical utility prior to the onset of neuropsychiatric symptoms. We retrospectively analyzed 35 NPSLE patients, 34 SLE patients, 20 viral meningitis (VM) patients, and 16 relapsing-remitting multiple sclerosis (MS) patients. We measured anti-suprabasin antibodies concentrations in serum by using Luciferase immunoprecipitation system (LIPS) assay. The serum concentrations of cytokines/chemokines were measured by using multiplex bead-based assay. We found serum FGF-2 level was significantly higher in the NPSLE group compared to the SLE group and the healthy control group. The anti-suprabasin antibody relative concentration (SRC) has high positive predictive values for the development of NPSLE. The most essential biomarkers are VEGF, anti-suprabasin antibodies, sCD40L, IL-10, GRO, MDC, IL-8, IL-9, TNF-α, MIP-1α., 長崎大学学位論文 学位記番号:共博(医歯薬)甲第23号 学位授与年月日:令和4年9月16日, Author: Trang T.T. Hoang, Kunihiro Ichinose, Shimpei Morimoto, Kaori Furukawa, Ly H.T. Le, Atsushi Kawakami, Citation: Clinical Immunology, 237, art.no.108980; 2022, Nagasaki University (長崎大学), 博士(医学) (2022-09-16)},
 school = {Nagasaki University (長崎大学)},
 title = {Measurement of anti-suprabasin antibodies, multiple cytokines and chemokines as potential predictive biomarkers for neuropsychiatric systemic lupus erythematosus},
 year = {2022}
}