{"created":"2023-05-15T16:49:57.876190+00:00","id":27634,"links":{},"metadata":{"_buckets":{"deposit":"207ccd6e-c548-44d9-bbbb-2040fc2ef02e"},"_deposit":{"created_by":6,"id":"27634","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"27634"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00027634","sets":["10:11"]},"author_link":["122841","122839","122836","122833","122838","122835","122840","122837","122842","122834"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-09-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"935","bibliographicVolumeNumber":"5","bibliographic_titles":[{"bibliographic_title":"Communications Biology"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"SLITRK1 is an obsessive-compulsive disorder spectrum-disorders-ssociated gene that encodes a neuronal transmembrane protein. Here we show that SLITRK1 suppresses noradrenergic projections in the neonatal prefrontal cortex, and SLITRK1 functions are impaired by SLITRK1 mutations in patients with schizophrenia (S330A, a revertant of Homo sapiensspecific residue) and bipolar disorder (A444S). Slitrk1-KO newborns exhibit abnormal vocalizations, and their prefrontal cortices show excessive noradrenergic neurites and reduced Semaphorin3A expression, which suppresses noradrenergic neurite outgrowth in vitro. Slitrk1 can bind Dynamin1 and L1 family proteins (Neurofascin and L1CAM), as well as suppress Semaphorin3A-induced endocytosis. Neurofascin-binding kinetics is altered in S330A and A444S mutations. Consistent with the increased obsessive-compulsive disorder prevalence in males in childhood, the prefrontal cortex of male Slitrk1-KO newborns show increased noradrenaline levels, and serotonergic varicosity size. This study further elucidates the role of noradrenaline in controlling the development of the obsessive-compulsive disorder-related neural circuit.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Communications Biology, 5 (1), art. no. 935　","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/s42003-022-03891-y","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/. © The Author(s) 2022"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2399-3642","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hatayama, Minoru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Katayama, Kei-ichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawahara, Yukie"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsunaga, Hayato"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takashima, Noriko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iwayama, Yoshimi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsumoto, Yoshifumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishi, Akinori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshikawa, Takeo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Aruga, Jun"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-10-06"}],"displaytype":"detail","filename":"CB5_935.pdf","filesize":[{"value":"4.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"CB5_935.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/27634/files/CB5_935.pdf"},"version_id":"6bdab4e4-576d-4483-b0da-98821d399907"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"SLITRK1-mediated noradrenergic projection suppression in the neonatal prefrontal cortex","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"SLITRK1-mediated noradrenergic projection suppression in the neonatal prefrontal cortex"}]},"item_type_id":"2","owner":"6","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-10-06"},"publish_date":"2022-10-06","publish_status":"0","recid":"27634","relation_version_is_last":true,"title":["SLITRK1-mediated noradrenergic projection suppression in the neonatal prefrontal cortex"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-05-15T19:35:48.240685+00:00"}