{"created":"2023-05-15T16:49:58.668690+00:00","id":27652,"links":{},"metadata":{"_buckets":{"deposit":"3b0b4a87-9e65-4f20-badc-fdb7577e5168"},"_deposit":{"created_by":6,"id":"27652","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"27652"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00027652","sets":["10:11"]},"author_link":["123005","123002","122998","123003","123001","122999","123000","123004"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-09-23","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageStart":"e0275175","bibliographicVolumeNumber":"17","bibliographic_titles":[{"bibliographic_title":"PLOS ONE"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: Immobilization of skeletal muscles causes muscle atrophy, muscle contracture, and muscle pain, the mechanisms of which are related to macrophage accumulation. However, muscle contractile exercise through a belt electrode device may mitigate macrophage accumula-tion. We hypothesized that such exercise would be effective in preventing myofiber atrophy, muscle contracture, and muscular pain. This study tested this hypothesis in immobilized rat gastrocnemius muscle.\nMaterials and methods: A total of 32 rats were divided into the following control and experimental groups: immobili-zation (immobilized treatment only), low-frequency (LF; immobilized treatment and muscle contractile exercise with a 2 s (do) /6 s (rest) duty cycle), and high-frequency (HF; immobi-lized treatment and muscle contractile exercise with a 2 s (do)/2 s (rest) duty cycle). Electri-cal stimulation was performed at 50 Hz and 4.7 mA, and muscle contractile exercise was applied to the lower limb muscles for 15 or 20 min/session (once daily) for 2 weeks (6 times/ week). After the behavioral tests, the bilateral gastrocnemius muscles were collected for analysis.\nResults: The number of macrophages, the Atrogin-1 and MuRF-1 mRNA expression, and the hydroxyproline content in the HF group were lower than those in the immobilization and LF groups. The cross-sectional area (CSA) of type IIb myofibers in the superficial region, the PGC-1α mRNA expression, and the range of motion of dorsiflexion in the HF group were significantly higher than those in the immobilization and LF groups. The pressure pain thresholds in the LF and HF groups were significantly higher than that in the immobilization group, and the nerve growth factor (NGF) content in the LF and HF groups was significantly lower than that in the immobilization group.\nConclusion: Muscle contractile exercise through the belt electrode device may be effective in preventing immobilization-induced myofiber atrophy, muscle contracture, and muscular pain in the immobilized rat gastrocnemius muscle.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"PLoS ONE, 17(9), art. no. e0275175; 2022","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"PLOS"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1371/journal.pone.0275175","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2022 Honda et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1932-6203","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Honda, Yuichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takahashi, Ayumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanaka, Natsumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kajiwara, Yasuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sasaki, Ryo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okita, Seima"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakamoto, Junya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okita, Minoru"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-10-13"}],"displaytype":"detail","filename":"PLOSO17_e0275175.pdf","filesize":[{"value":"2.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PLOSO17_e0275175.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/27652/files/PLOSO17_e0275175.pdf"},"version_id":"062f86bb-1fe3-4f60-8e84-7b493e7cd3de"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Muscle contractile exercise through a belt electrode device prevents myofiber atrophy, muscle contracture, and muscular pain in immobilized rat gastrocnemius muscle","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Muscle contractile exercise through a belt electrode device prevents myofiber atrophy, muscle contracture, and muscular pain in immobilized rat gastrocnemius muscle"}]},"item_type_id":"2","owner":"6","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-10-13"},"publish_date":"2022-10-13","publish_status":"0","recid":"27652","relation_version_is_last":true,"title":["Muscle contractile exercise through a belt electrode device prevents myofiber atrophy, muscle contracture, and muscular pain in immobilized rat gastrocnemius muscle"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-05-15T19:34:50.246386+00:00"}