{"created":"2023-05-15T16:49:59.743114+00:00","id":27678,"links":{},"metadata":{"_buckets":{"deposit":"d04354d8-c097-47a7-924b-2d4a7e6236cb"},"_deposit":{"created_by":6,"id":"27678","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"27678"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00027678","sets":["12:13"]},"author_link":["123110","123102","123104","123112","123098","123096","123108","123113","123100","123101","123105","123107","123103","123111","123097","123099","123109","123106"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-10-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"75","bibliographicVolumeNumber":"50","bibliographic_titles":[{"bibliographic_title":"Tropical Medicine and Health"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: SARS-CoV-2 seroepidemiological studies are used to guide public health decision making and to prepare for emerging infectious diseases. Disease occurrence estimates are limited in the Philippines, the country with the highest reported number of coronavirus disease-related deaths in the Western Pacific region. We aimed to estimate SARS-CoV-2 seroprevalence and infection rate among outpatient clinic attendees in Metro Manila prior to the implementation of the national coronavirus disease vaccination program. \nMethods: We conducted repeated cross-sectional surveys at the animal bite clinic in San Lazaro Hospital, Manila, the Philippines across four periods, 3 months apart, between May 2020 and March 2021. Multivariable logistic regression was used to assess associations between different characteristics and infection status including seropositivity.\nResults: In total 615 participants were enrolled, ranging from 115 to 174 per period. Seroprevalence quadrupled between the first (11.3%) and second (46.8%) periods and plateaued thereafter (third—46.0%, fourth—44.6%). Among seropositive participants, total antibody concentration was comparable throughout the first to third periods but declined between the third and fourth periods. Infection prevalence was comparable across enrollment periods (range 2.9–9.5%). Post-secondary education [aOR 0.42 (95% CI 0.26, 0.67)] was protective, and frontline work [aOR 1.81 (95% CI 1.18, 2.80)] was associated with increased odds of seropositivity. Frontline work status [aOR 2.27 (95% CI 1.10, 4.75)] and large household size [aOR 2.45 (95% CI 1.18, 5.49)] were associated with increased odds of infection.\nConclusions: The quadrupling of seroprevalence over 3 months between the first and second enrollment periods coincided with the high burden of infection in Metro Manila in early 2020. Our findings suggest a limit to the rise and potential decline of population-level SARS-CoV-2 infection-induced immunity without introduction of vaccines. These results may add to our understanding of how immunity develops against emerging infectious diseases including coronaviruses.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Tropical Medicine and Health, 50(1), art. no. 75; 2022　","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"BioMed Central Ltd"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1186/s41182-022-00468-7","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1349-4147","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Malijan, Greco Mark B."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Edwards, Tansy"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Agrupis, Kristal An"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Shuichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Villanueva, Annavi Marie G."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sayo, Ana Ria"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"De Guzman, Ferdinand"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Dimapilis, Alexis Q."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Solante, Rontgene M."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Telan, Elizabeth O."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Umipig, Dorcas V."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ota, Kenji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishimura, Fumitaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yanagihara, Katsunori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Salazar, Mary Jane"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Lopez, Edmundo B."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ariyoshi, Koya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Smith, Chris"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-10-25"}],"displaytype":"detail","filename":"TMH50_75.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"TMH50_75.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/27678/files/TMH50_75.pdf"},"version_id":"b9ca51db-34ec-4d47-8e34-ebf6f2a9d84a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"SARS-CoV-2","subitem_subject_scheme":"Other"},{"subitem_subject":"COVID-19","subitem_subject_scheme":"Other"},{"subitem_subject":"Seroepidemiological study","subitem_subject_scheme":"Other"},{"subitem_subject":"Philippines","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"SARS-CoV-2 seroprevalence and infection rate in Manila, Philippines prior to national vaccination program implementation: a repeated cross-sectional analysis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"SARS-CoV-2 seroprevalence and infection rate in Manila, Philippines prior to national vaccination program implementation: a repeated cross-sectional analysis"}]},"item_type_id":"2","owner":"6","path":["13"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-10-25"},"publish_date":"2022-10-25","publish_status":"0","recid":"27678","relation_version_is_last":true,"title":["SARS-CoV-2 seroprevalence and infection rate in Manila, Philippines prior to national vaccination program implementation: a repeated cross-sectional analysis"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-05-15T19:33:39.155026+00:00"}