{"created":"2023-05-15T16:49:59.829372+00:00","id":27680,"links":{},"metadata":{"_buckets":{"deposit":"221f1eb0-b7db-4d95-bcd6-c819d6ef9bbd"},"_deposit":{"created_by":6,"id":"27680","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"27680"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00027680","sets":["2030:2031"]},"author_link":["123128","123130","123120","123123","123135","123122","123141","123140","123124","123129","123137","123142","123131","123139","123125","123134","123121","123133","123127","123136","123138","123132","123126"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-10-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageStart":"001796","bibliographicVolumeNumber":"103","bibliographic_titles":[{"bibliographic_title":"Journal of General Virology"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In Africa, several emerging zoonotic viruses have been transmitted from small mammals such as rodents and shrews to humans. Although no clinical cases of small mammal-borne viral diseases have been reported in Central Africa, potential zoonotic viruses have been identified in rodents in the region. Therefore, we hypothesized that there may be unrecognized zoonotic viruses circulating in small mammals in Central Africa. Here, we investigated viruses that have been maintained among wild small mammals in Gabon to understand their potential risks to humans. We identified novel orthonairoviruses in 24.6 % of captured rodents and shrews from their kidney total RNA samples. Phylogenetic analysis revealed that the novel viruses, Lamusara virus (LMSV) and Lamgora virus, were closely related to Erve virus, which was previously identified in shrews of the genus Crocidura and has been suspected to cause neuropathogenic diseases in humans. Moreover, we show that the LMSV ovarian tumour domain protease, one of the virulence determination factors of orthonairoviruses, suppressed interferon signalling in human cells, suggesting the possible human pathogenicity of this virus. Taken together, our study demonstrates the presence of novel orthonairoviruses that may pose unrecognized risks of viral disease transmission in Gabon.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"The Journal of general virology, 103(10), art. no. 001796; 2022　","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Microbiology Society"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1099/jgv.0.001796","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2022 The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-1317","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ozeki, Takehiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Abe, Haruka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ushijima, Yuri"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nze-Nkogue, Chimène"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Akomo-Okoue, Etienne F."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ella, Ghislain W.E."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Koumba, Lilian B.M."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nso, Branly C.B.B."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mintsa-Nguema, Rodrigue"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Makouloutou-Nzassi, Patrice"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Makanga, Boris K."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nguelet, Fred L.M."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ondo, Georgelin N."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mbadinga, Marien J.V.M."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Igasaki, Yui"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okada, Sayaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hirano, Minato"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshii, Kentaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Lell, Bertrand"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Bonney, Laura C."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hewson, Roger"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kurosaki, Yohei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yasuda, Jiro"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-10-25"}],"displaytype":"detail","filename":"JGV103_001796.pdf","filesize":[{"value":"3.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JGV103_001796.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/27680/files/JGV103_001796.pdf"},"version_id":"676da1c7-0284-4e2d-9eec-8a8911ec6a00"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Orthonairovirus","subitem_subject_scheme":"Other"},{"subitem_subject":"small mammals","subitem_subject_scheme":"Other"},{"subitem_subject":"novel virus","subitem_subject_scheme":"Other"},{"subitem_subject":"Gabon","subitem_subject_scheme":"Other"},{"subitem_subject":"virus screening","subitem_subject_scheme":"Other"},{"subitem_subject":"surveillance","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Identification of novel orthonairoviruses from rodents and shrews in Gabon, Central Africa","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Identification of novel orthonairoviruses from rodents and shrews in Gabon, Central Africa"}]},"item_type_id":"2","owner":"6","path":["2031"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-10-25"},"publish_date":"2022-10-25","publish_status":"0","recid":"27680","relation_version_is_last":true,"title":["Identification of novel orthonairoviruses from rodents and shrews in Gabon, Central Africa"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-05-15T19:33:47.876388+00:00"}