{"created":"2023-05-15T16:50:01.351629+00:00","id":27716,"links":{},"metadata":{"_buckets":{"deposit":"c3a6cce1-7901-4646-9ea4-a13a10cdd733"},"_deposit":{"created_by":6,"id":"27716","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"27716"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00027716","sets":["29:30:1713167819629:2042"]},"author_link":["123269","123272","123275","123271","123266","123273","123276","123274","123268","123270","123267"],"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"19","bibliographicPageStart":"13","bibliographicVolumeNumber":"66","bibliographic_titles":[{"bibliographic_title":"Acta medica Nagasakiensia"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: The impact of neoadjuvant chemotherapy for locally advanced colorectal cancer has not yet been investigated; thus, this study aimed to examine the safety, feasibility, and oncological effects of neoadjuvant chemotherapy for locally advanced colorectal cancer.\nMethods: In this multicenter study, we retrospectively reviewed the data of 83 locally advanced colorectal cancer patients (cT3/4 or N1/2) who received neoadjuvant chemotherapy followed by radical resection between April 2016 and September 2020. The NAC regimens were FOLFOX (5-fluorouracil, leucovorin, and oxaliplatin), XELOX (capecitabine and oxaliplatin), or SOX (S-1 and oxaliplatin). We evaluated the pathological responses as well as the short- and long-term outcomes.\nResults: A pathological complete response was achieved in 4 patients (4.8%). Tumor down-staging and nodal down-staging were achieved in 57 (68.7%) and 49 (59.0%) patients, respectively. One patient (1.2%) experienced progressive disease. Postoperative complications occurred in 21 patients (25.3%). Multivariate analysis revealed that the pathological N positive status (p = 0.015; odds ratio, 4.458; 95% confidence interval, 1.331 to 7.9300) was an independent predictive factor for relapse-free survival.\nConclusion: Neoadjuvant chemotherapy for colorectal cancer could achieve good tumor control and down-staging without increasing the rate of complications. Appropriate preoperative treatment that can reduce the rate of the pathological nodepositive disease may improve oncological outcomes.","subitem_description_type":"Abstract"}]},"item_3_description_64":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Acta medica Nagasakiensia, 66(1), pp.13-19; 2022","subitem_description_type":"Other"}]},"item_3_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nagasaki University School of Medicine"}]},"item_3_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508430","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00016055","subitem_source_identifier_type":"ISSN"}]},"item_3_text_62":{"attribute_name":"sortkey","attribute_value_mlt":[{"subitem_text_value":"03"}]},"item_3_text_63":{"attribute_name":"出版者別言語","attribute_value_mlt":[{"subitem_text_value":"長崎大学医学部"}]},"item_3_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Noda, Keisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tominaga, Tetsuro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nonaka, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Araki, Masato"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sumida, Yorihisa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takeshita, Hiroaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukuoka, Hidetoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"To, Kazuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanaka, Kenji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sawai, Terumitsu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagayasu, Takeshi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-10-28"}],"displaytype":"detail","filename":"ActMed66_13.pdf","filesize":[{"value":"611.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ActMed66_13.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/27716/files/ActMed66_13.pdf"},"version_id":"7e3178e4-65bb-4767-945a-cda84ec20251"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"neoadjuvant chemotherapy","subitem_subject_scheme":"Other"},{"subitem_subject":"colorectal cancer","subitem_subject_scheme":"Other"},{"subitem_subject":"pathological node-positive","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Neoadjuvant chemotherapy in locally advanced colorectal cancer: a Japanese multicenter study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Neoadjuvant chemotherapy in locally advanced colorectal cancer: a Japanese multicenter study"}]},"item_type_id":"3","owner":"6","path":["2042"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-10-28"},"publish_date":"2022-10-28","publish_status":"0","recid":"27716","relation_version_is_last":true,"title":["Neoadjuvant chemotherapy in locally advanced colorectal cancer: a Japanese multicenter study"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2024-04-17T04:20:14.365365+00:00"}