{"created":"2023-05-15T16:50:01.395477+00:00","id":27717,"links":{},"metadata":{"_buckets":{"deposit":"f645d579-b05d-45bd-8b42-c2f8ea5ba4a8"},"_deposit":{"created_by":6,"id":"27717","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"27717"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00027717","sets":["29:30:1713167819629:2042"]},"author_link":["123277","123278","123280","123279"],"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"27","bibliographicPageStart":"21","bibliographicVolumeNumber":"66","bibliographic_titles":[{"bibliographic_title":"Acta medica Nagasakiensia"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective: Epidemiological studies have identified various predictors of conversion from ocular myasthenia gravis (OMG) to secondary generalized myasthenia gravis (SGMG), but none have been confirmed. We investigated the effects of the epidemiological conversion predictors on the destruction of motor endplates in the biceps of patients with OMG and attempted to identify predictors of conversion to SGMG histologically.\nMethods: Patients with clinically diagnosed OMG who requested immunohistological diagnosis and who underwent muscle biopsy were included in this study. We immunostained the biceps motor endplate and semi-quantitatively measured the density and number of AChRs to determine their association with the epidemiological predictors of conversion from OMG to SGMG.\nResults: Thirteen patients with OMG were included, of which two patients with positive AChR antibody and concomitant thymoma converted to SGMG. In the classification according to the presence of AChR antibody, the AChR densities tended to be lower in the antibody-positive group than in the negative group (p=0.079), and the AChR numbers were significantly lesser in the AChR antibody-positive group than in the negative group (p=0.019). There were no differences in AChR densities or numbers according to sex, presence of thymic abnormalities, or presence of comorbid autoimmune diseases.\nConclusion: In OMG, the AChR numbers in motor endplates of the biceps were significantly lesser in the AChR antibodypositive group than in the negative group. Since the muscle strength tends to decrease as the number of AChRs decreases, AChR antibody positivity may be a predictor of OMG to SGMG conversion, but further studies are needed to confirm.","subitem_description_type":"Abstract"}]},"item_3_description_64":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Acta medica Nagasakiensia, 66(1), pp.21-27; 2022","subitem_description_type":"Other"}]},"item_3_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nagasaki University School of Medicine"}]},"item_3_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508430","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00016055","subitem_source_identifier_type":"ISSN"}]},"item_3_text_62":{"attribute_name":"sortkey","attribute_value_mlt":[{"subitem_text_value":"04"}]},"item_3_text_63":{"attribute_name":"出版者別言語","attribute_value_mlt":[{"subitem_text_value":"長崎大学医学部"}]},"item_3_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shima, Tomoaki"}],"nameIdentifiers":[{"nameIdentifier":"123277","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nagaoka, Atsushi"}],"nameIdentifiers":[{"nameIdentifier":"123278","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshimura, Shunsuke"}],"nameIdentifiers":[{"nameIdentifier":"123279","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsujino, Akira"}],"nameIdentifiers":[{"nameIdentifier":"123280","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-10-28"}],"displaytype":"detail","filename":"ActMed66_21.pdf","filesize":[{"value":"585.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ActMed66_21.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/27717/files/ActMed66_21.pdf"},"version_id":"35bee370-da7b-44e4-8329-bf2e7539293e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ocular myasthenia gravis","subitem_subject_scheme":"Other"},{"subitem_subject":"secondary generalized myasthenia gravis","subitem_subject_scheme":"Other"},{"subitem_subject":"acetylcholine receptor antibody","subitem_subject_scheme":"Other"},{"subitem_subject":"motor endplate","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Association between acetylcholine receptor characteristics in biceps motor endplates and the epidemiological predictors for conversion from ocular to generalized myasthenia gravis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Association between acetylcholine receptor characteristics in biceps motor endplates and the epidemiological predictors for conversion from ocular to generalized myasthenia gravis"}]},"item_type_id":"3","owner":"6","path":["2042"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-10-28"},"publish_date":"2022-10-28","publish_status":"0","recid":"27717","relation_version_is_last":true,"title":["Association between acetylcholine receptor characteristics in biceps motor endplates and the epidemiological predictors for conversion from ocular to generalized myasthenia gravis"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2024-04-17T04:20:12.692539+00:00"}