{"created":"2023-05-15T16:50:03.821738+00:00","id":27771,"links":{},"metadata":{"_buckets":{"deposit":"64860575-4cea-485e-94fe-7b33382af161"},"_deposit":{"created_by":6,"id":"27771","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"27771"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00027771","sets":["10:11"]},"author_link":["123495","123485","123489","123488","123490","123493","123484","123487","123486","123494","123492","123491"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-11-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageStart":"e0275439","bibliographicVolumeNumber":"17","bibliographic_titles":[{"bibliographic_title":"PLOS ONE"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose\nImmobilization osteopenia is a major healthcare problem in clinical and social medicine. However, the mechanisms underlying this bone pathology caused by immobilization under load-bearing conditions are not yet fully understood. This study aimed to evaluate sequential changes to the three-dimensional microstructure of bone in load-bearing immobilization osteopenia using a fixed-limb rat model.\nMaterials and method\nEight-week-old specific-pathogen-free male Wistar rats were divided into an immobilized group and a control group (n = 60 each). Hind limbs in the immobilized group were fixed using orthopedic casts with fixation periods of 1, 2, 4, 8, and 12 weeks. Feeding and weight-bearing were freely permitted. Length of the right femur was measured after each fixation period and bone microstructure was analyzed by micro-computed tomography. The architectural parameters of cortical and cancellous bone were analyzed statistically.\nResults\nFemoral length was significantly shorter in the immobilized group than in the control group after 2 weeks. Total area and marrow area were significantly lower in the immobilized group than in the control group from 1 to 12 weeks. Cortical bone area, cortical thickness, and polar moment of inertia decreased significantly after 2 weeks. Some cancellous bone parameters showed osteoporotic changes at 2 weeks after immobilization and the gap with the control group widened as the fixation period extended (P < 0.05).\nConclusion\nThe present results indicate that load-bearing immobilization triggers early deterioration of microstructure in both cortical and cancellous bone after 2 weeks.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"PLoS ONE, 17(11), art. no. e0275439; 2022","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"PLOS"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1371/journal.pone.0275439","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2022 Koseki et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1932-6203","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Koseki, Hironobu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Osaki, Makoto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Honda, Yuichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sunagawa, Shinya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Imai, Chieko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shida, Takayuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsumura, Umi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakamoto, Junya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tomonaga, Iku"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yokoo, Seiichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mizukami, Satoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okita, Minoru"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-11-24"}],"displaytype":"detail","filename":"PLOSO17_e0275439.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PLOSO17_e0275439.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/27771/files/PLOSO17_e0275439.pdf"},"version_id":"14919773-bb47-420b-a6c3-97581bc69b1e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Progression of microstructural deterioration in load-bearing immobilization osteopenia","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Progression of microstructural deterioration in load-bearing immobilization osteopenia"}]},"item_type_id":"2","owner":"6","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-11-24"},"publish_date":"2022-11-24","publish_status":"0","recid":"27771","relation_version_is_last":true,"title":["Progression of microstructural deterioration in load-bearing immobilization osteopenia"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-05-15T19:22:15.161952+00:00"}