{"created":"2023-05-15T16:50:04.194993+00:00","id":27779,"links":{},"metadata":{"_buckets":{"deposit":"2e4bf48a-0b81-4460-a644-c3a96eb89ebc"},"_deposit":{"created_by":6,"id":"27779","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"27779"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00027779","sets":["8:9"]},"author_link":["123543","123539","123542","123538","123540","123541"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-10-19","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageStart":"431","bibliographicVolumeNumber":"24","bibliographic_titles":[{"bibliographic_title":"Oncology Letters"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Salvage surgery for recurrent oral squamous cell carcinoma (OSCC) often leads to a poor quality of life (QOL). The present study described three cases that resulted in favorable locoregional control with cetuximab in combination with radiotherapy (Cmab + RT). Case 1 had regional recurrence of OSCC at the lower right mastoid area 4 months after primary surgery. Case 2 had regional recurrence of OSCC at the parotid area 7 months after primary surgery. Case 3 had local recurrence of OSCC at the masticatory muscle and Rouviere's lymph nodes 1 year and 3 months after primary surgery. In all cases, Cmab + RT was performed, and disease‑free survival was confirmed 4 months, 2 years and 6 months, and 10 months after Cmab + RT, respectively. Immunohistochemically, all resected tumors had no expression of 110‑kDa catalytic subunit of class IA phosphatidylinositol 3‑kinase (PI3Kp110α). In conclusion, if salvage surgery for recurrent OSCC results in a significantly low QOL, then shifting to chemoradiotherapy may be appropriate as a treatment strategy. In addition, strong evidence indicated that PI3Kp110α expression is associated with Cmab therapy efficacy.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Oncology Letters, 24(6), art. no. 431; 2022　","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Spandidos Publications"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3892/ol.2022.13551","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) License."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1792-1074","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Naruse, Tomofumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Furukawa, Kohei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyoshi, Taro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Morishita, Kota"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Otsuru, Mitsunobu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Umeda, Masahiro"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-11-29"}],"displaytype":"detail","filename":"OL24_431.pdf","filesize":[{"value":"4.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"OL24_431.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/27779/files/OL24_431.pdf"},"version_id":"87d1543d-6978-466e-b2c9-6097bb9cd359"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Cmab","subitem_subject_scheme":"Other"},{"subitem_subject":"RT","subitem_subject_scheme":"Other"},{"subitem_subject":"locoregional recurrence","subitem_subject_scheme":"Other"},{"subitem_subject":"PI3Kp110α","subitem_subject_scheme":"Other"},{"subitem_subject":"salvage surgery","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Complete response of recurrent oral squamous cell carcinoma treated with cetuximab in combination with radiotherapy: A case series","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Complete response of recurrent oral squamous cell carcinoma treated with cetuximab in combination with radiotherapy: A case series"}]},"item_type_id":"2","owner":"6","path":["9"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-11-29"},"publish_date":"2022-11-29","publish_status":"0","recid":"27779","relation_version_is_last":true,"title":["Complete response of recurrent oral squamous cell carcinoma treated with cetuximab in combination with radiotherapy: A case series"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-05-15T19:17:09.827921+00:00"}