{"created":"2023-05-15T16:50:06.351677+00:00","id":27828,"links":{},"metadata":{"_buckets":{"deposit":"9e174bde-7163-4594-9ae5-4293f1695df8"},"_deposit":{"created_by":6,"id":"27828","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"27828"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00027828","sets":["8:9"]},"author_link":["123926","123925","123924","123931","123928","123929","123930","123927"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-12-26","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"227","bibliographicVolumeNumber":"22","bibliographic_titles":[{"bibliographic_title":"BMC Medical Imaging"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nerve system caused by the John Cunningham virus. On MRI, PML may sometimes appear similar to primary central nervous system lymphoma (PCNSL) and glioblastoma multiforme (GBM). The purpose of this pilot study was to evaluate the potential of amide proton transfer (APT) imaging for differentiating PML from PCNSL and GBM. Methods: Patients with PML (n = 4; two men; mean age 52.3 ± 6.1 years), PCNSL (n = 7; four women; mean age 74.4 ± 5.8 years), or GBM (n = 11; 6 men; mean age 65.0 ± 15.2 years) who underwent APT-CEST MRI between January 2021 and September 2022 were retrospectively evaluated. Magnetization transfer ratio asymmetry (MTRasym) values were measured on APT imaging using a region of interest within the lesion. Receiver operating characteristics curve analysis was used to determine diagnostic cutoffs for MTRasym. Results: The mean MTRasym values were 0.005 ± 0.005 in the PML group, 0.025 ± 0.005 in the PCNSL group, and 0.025 ± 0.009 in the GBM group. There were significant differences in MTRasym between PML and PCNSL (P = 0.023), and between PML and GBM (P = 0.015). For differentiating PML from PCNSL, an MTRasym threshold of 0.0165 gave diagnostic sensitivity, specificity, positive predictive value, and negative predictive value of 100% (all). For differentiating PML from GBM, an MTRasym threshold of 0.015 gave diagnostic sensitivity, specificity, positive predictive value, and negative predictive value of 100%, 90.9%, 80.0%, and 100%, respectively. Conclusion: MTRasym values obtained from APT imaging allowed patients with PML to be clearly discriminated from patients with PCNSL or GBM.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"BMC Medical Imaging, 22(1), art. no. 227; 2022　","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"BMC"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1186/s12880-022-00959-3","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1471-2342","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Koike, Hirofumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Morikawa, Minoru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishimaru, Hideki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ideguchi, Reiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Uetani, Masataka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hiu, Takeshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuo, Takayuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyoshi, Mitsuharu"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-01-13"}],"displaytype":"detail","filename":"BMCMI22_227.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"BMCMI22_227.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/27828/files/BMCMI22_227.pdf"},"version_id":"a72590c8-d273-4b5e-8f20-238ea4bd7abd"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Magnetic resonance imaging","subitem_subject_scheme":"Other"},{"subitem_subject":"Amide proton transfer imaging","subitem_subject_scheme":"Other"},{"subitem_subject":"Progressive multifocal leukoencephalopathy","subitem_subject_scheme":"Other"},{"subitem_subject":"Primary central nervous system lymphoma","subitem_subject_scheme":"Other"},{"subitem_subject":"Glioblastoma multiforme","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Amide proton transfer MRI differentiates between progressive multifocal leukoencephalopathy and malignant brain tumors: a pilot study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Amide proton transfer MRI differentiates between progressive multifocal leukoencephalopathy and malignant brain tumors: a pilot study"}]},"item_type_id":"2","owner":"6","path":["9"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-01-13"},"publish_date":"2023-01-13","publish_status":"0","recid":"27828","relation_version_is_last":true,"title":["Amide proton transfer MRI differentiates between progressive multifocal leukoencephalopathy and malignant brain tumors: a pilot study"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-05-15T18:17:02.977980+00:00"}