{"created":"2023-05-15T16:50:06.954252+00:00","id":27842,"links":{},"metadata":{"_buckets":{"deposit":"2d54127c-c254-4a4b-a3a7-69588664b5ee"},"_deposit":{"created_by":6,"id":"27842","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"27842"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00027842","sets":["10:11"]},"author_link":["124031","124036","124032","124038","124034","124037","124029","124035","124033","124030"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-12-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"183","bibliographicVolumeNumber":"15","bibliographic_titles":[{"bibliographic_title":"Nutrients"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aggressive endothelial repair results in the progression of both structural and functional atherosclerosis, while insufficient endothelial repair worsens functional but not structural atherosclerosis. Aging increases the risk of inadequate endothelial repair. Since low-density lipoprotein cholesterol (LDLc) activates endothelial repair, LDLc may be positively associated with structural atherosclerosis but inversely associated with functional atherosclerosis in older individuals. This cross-sectional study analyzed 1458 participants aged 60 to 79 years. We defined structural atherosclerosis as a carotid intima-media thickness (CIMT) of at least 1.1 mm and functional atherosclerosis as a cardio-ankle vascular index (CAVI) of at least 9.0. LDLc was significantly positively associated with structural atherosclerosis and significantly inversely associated with functional atherosclerosis, independently of known cardiovascular risk factors. For 1 standard increment of LDLc (28 mg/dL for men and 29 mg/dL for women), the odds ratios and 95% confidence intervals after adjustment for known cardiovascular risk factors were 1.28 (1.10, 1.50) for structural atherosclerosis and 0.85 (0.75, 0.96) for functional atherosclerosis. LDLc activates endothelial repair, which results in the development of structural atherosclerosis but maintains endothelial function in older individuals. To evaluate atherosclerosis in clinical practice, the combination of structural and functional assessment of atherosclerosis could be informative.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Nutrients, 15(1), art. no. 183; 2022","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3390/nu15010183","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2072-6643","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shimizu, Yuji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamanashi, Hirotomo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Honda, Yukiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nonaka, Fumiaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyata, Jun"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawashiri, Shin-Ya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Noguchi, Yuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamichi, Seiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagata, Yasuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Maeda, Takahiro"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-01-19"}],"displaytype":"detail","filename":"N15_183.pdf","filesize":[{"value":"282.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"N15_183.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/27842/files/N15_183.pdf"},"version_id":"bf5db2a5-adcf-40d3-b258-ebe4a19d546a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"LDL","subitem_subject_scheme":"Other"},{"subitem_subject":"structural atherosclerosis","subitem_subject_scheme":"Other"},{"subitem_subject":"functional atherosclerosis","subitem_subject_scheme":"Other"},{"subitem_subject":"CIMT","subitem_subject_scheme":"Other"},{"subitem_subject":"CAVI","subitem_subject_scheme":"Other"},{"subitem_subject":"older","subitem_subject_scheme":"Other"},{"subitem_subject":"endothelial repair","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Low-Density Lipoprotein Cholesterol, Structural Atherosclerosis, and Functional Atherosclerosis in Older Japanese","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Low-Density Lipoprotein Cholesterol, Structural Atherosclerosis, and Functional Atherosclerosis in Older Japanese"}]},"item_type_id":"2","owner":"6","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-01-19"},"publish_date":"2023-01-19","publish_status":"0","recid":"27842","relation_version_is_last":true,"title":["Low-Density Lipoprotein Cholesterol, Structural Atherosclerosis, and Functional Atherosclerosis in Older Japanese"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-05-15T18:16:29.424050+00:00"}