@article{oai:nagasaki-u.repo.nii.ac.jp:00027891,
 author = {Hieu, Truong Hong and Ngoc Thao, Pham Thi and Cucè, Federica and Nam, Nguyen Hai and Reda, Abdullah and Hassan, Osman Gamal and Hung, Le Thanh and Kim Quyen, Dinh Thi and Abdul Aziz, Jeza M and Le Quang, Loc and Carameros, Alison Marie and Huy, Nguyen Tien},
 issue = {5},
 journal = {Hospital Practice},
 month = {Nov},
 note = {Background: Sepsis and septic shock have high mortality rates and often require a prolonged hospital stay. Patient outcomes may vary according to multiple factors. We aim to determine the prevalence of antimicrobial resistance and factors associated with mortality and hospital stay.
Methods: Clinical and microbiological data of patients with sepsis or septic shock were retrospectively collected for 15 months. Patients with negative blood cultures and patients that did not meet the SEPSIS 3 criteria were excluded.
Results: We included 48 septic shock and 28 septic patients (mean APACHE II 20.32 ± 5.61 and mean SOFA 9.41 ± 3.17), with a mean age of 60.5 ± 16.8 years and 56.6% males. WBCs, neutrophils, INR, and fibrinogen levels were significantly associated with mortality. 59.5% of the cultured bacteria were gram-negative (most common E. coli) and 27.8% were gram-positive (most common S. aureus), while 7.6% were other types of bacteria and 5.1% were fungi. Resistance patterns to gram-negative were varying, and resistance to piperacillin/tazobactam, carbapenems, and aminoglycosides were from 60% to 100% (A. baumanii), while they were highly sensitive to Colistin. E. coli was also resistant to ceftriaxone (77.8%) and sulbactam/cefoperazone (44.4%). Resistance rates for Gram-positives were high, from 86% to 100% for oxacillin, while for vancomycin, teicoplanin, and linezolid, they were often low but arrived up to 42.8%. According to our logistic regression analysis, patients over 65 year-old and those who received corticosteroids had a significantly increased risk of in-hospital mortality (OR: 4.0; OR: 4.8).
Conclusion: Sepsis still poses a significant threat to patients’ health, even when positive blood culture results allow the administration of specific antibiotic treatment., Hospital Practice, 50(5), pp.407-415; 2022},
 pages = {407--415},
 title = {Burden and mortality of sepsis and septic shock at a high-volume, single-center in Vietnam: a retrospective study},
 volume = {50},
 year = {2022}
}