{"created":"2023-05-15T16:50:09.149189+00:00","id":27892,"links":{},"metadata":{"_buckets":{"deposit":"0d8214dc-7109-4e34-bd0f-31c683441c67"},"_deposit":{"created_by":6,"id":"27892","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"27892"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00027892","sets":["12:13"]},"author_link":["124348","124345","124349","124343","124341","124346","124344","124342","124347"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-01-31","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"29","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"Fundamental & Clinical Pharmacology"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Panax ginseng is a common natural product, which is well-known to have a wide range of pharmacological activities in cancer. Its metabolite, compound K (CK), has been reported to have anticancer activity. We aimed to systematically review the literature for evidence of anticancer effects of CK. We conducted a systematic search in eight databases. We included all in vitro and in vivo studies investigating the anticancer effects of CK with no restrictions. Quality assessment was applied by ToxRTool. Fifty-four articles were included in our study. The purity of CK in our included studies was at least 95%. The in vitro studies reported that CK had a potential anticancer activity on several cell lines including human lung cancer cell lines (A549, PC-9), nasopharyngeal carcinoma cell line (Hk-1), liver cancer cell line (BEL 7402), and pediatric acute myeloid leukemia cell lines (Kasumi-1, MV4-11). The in vivo studies reported a significant decrease in tumor volume in mice treated with CK. CK is a potential supplementary treatment in cancer chemotherapies. The safety and further clinical trials of CK should be explored for future drug development.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Fundamental & Clinical Pharmacology, pp.1-29; 2023. doi:10.1111/fcp.12874　","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"John Wiley & Sons, Inc."}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/fcp.12874","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2023 Société Française de Pharmacologie et de Thérapeutique. This is the peer reviewed version of the following article: https://onlinelibrary.wiley.com/doi/10.1111/fcp.12874, which has been published in final form at https://doi.org/10.1111/fcp.12874. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0767-3981","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tam, Dao Ngoc Hien"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nam, Nguyen Hai"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Cuong, Nguyen The Ky"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hung, Dang The"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Soa, Dang Thi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Altom, Ahmad"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tran, Linh"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Elhadad, Heba"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Huy, Nguyen Tien"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2024-01-31"}],"displaytype":"detail","filename":"FCP_1.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"FCP_1.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/27892/files/FCP_1.pdf"},"version_id":"2a973262-f714-45db-9492-6bd1514f56ec"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"anticancer","subitem_subject_scheme":"Other"},{"subitem_subject":"compound K","subitem_subject_scheme":"Other"},{"subitem_subject":"ginsenosides","subitem_subject_scheme":"Other"},{"subitem_subject":"in vitro","subitem_subject_scheme":"Other"},{"subitem_subject":"in vivo","subitem_subject_scheme":"Other"},{"subitem_subject":"systematic review","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Compound K: A systematic review of its anticancer properties and probable mechanisms","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Compound K: A systematic review of its anticancer properties and probable mechanisms"}]},"item_type_id":"2","owner":"6","path":["13"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-02-02"},"publish_date":"2023-02-02","publish_status":"0","recid":"27892","relation_version_is_last":true,"title":["Compound K: A systematic review of its anticancer properties and probable mechanisms"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-05-15T18:14:57.475804+00:00"}