{"created":"2023-05-15T16:50:11.085112+00:00","id":27938,"links":{},"metadata":{"_buckets":{"deposit":"69f2ef5e-f944-4512-afa9-be89555fd750"},"_deposit":{"created_by":6,"id":"27938","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"27938"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00027938","sets":["35:36"]},"author_link":["124638","124628","124634","124633","124626","124630","124635","124637","124631","124627","124632","124625","124636","124629","124639","124640"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-02-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageStart":"507","bibliographicVolumeNumber":"15","bibliographic_titles":[{"bibliographic_title":"Viruses"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The largest dengue outbreak in the history of Nepal occurred in 2022, with a significant number of casualties. It affected all 77 districts, with the nation’s capital, Kathmandu (altitude 1300 m), being the hardest hit. However, the molecular epidemiology of this outbreak, including the dengue virus (DENV) serotype(s) responsible for this epidemic, remain unknown. Here, we report the epidemic trends, clinico-laboratory features, and virus serotypes and their viral load profiles that are associated with this outbreak in Nepal. Dengue-suspected febrile patients were investigated by routine laboratory, serological, and molecular tools, including a real-time quantitative polymerase chain reaction (qRT-PCR). Of the 538 dengue-suspected patients enrolled, 401 (74.5%) were diagnosed with dengue. Among these dengue cases, 129 (32.2%) patients who required hospital admission had significant associations with myalgia, rash, diarrhea, retro-orbital pain, bleeding, and abdominal pain. DENV-1, -2, and -3 were identified during the 2022 epidemic, with a predominance of DENV-1 (57.1%) and DENV-3 (32.1%), exhibiting a new serotype addition. We found that multiple serotypes circulated in 2022, with a higher frequency of hospitalizations, more severe dengue, and more deaths than in the past. Therefore, precise mapping of dengue and other related infections through integrated disease surveillance, evaluation of the dynamics of population-level immunity and virus evolution should be the urgent plans of action for evidence-based policy-making for dengue control and prevention in the country.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Viruses, 15(2), art. no. 507; 2023","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3390/v15020507","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1999-4915","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Rimal, Sandesh"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shrestha, Sabin"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Pandey, Kishor"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nguyen, Thanh Vu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Bhandari, Parmananda"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shah, Yogendra"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Acharya, Dhiraj"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Adhikari, Nabaraj"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Rijal, Komal Raj"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ghimire, Prakash"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takamatsu, Yuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Pandey, Basu Dev"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fernandez, Stefan"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Morita, Kouichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ngwe Tun, Mya Myat"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Dumre, Shyam Prakash"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-06"}],"displaytype":"detail","filename":"V15_507.pdf","filesize":[{"value":"2.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"V15_507.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/27938/files/V15_507.pdf"},"version_id":"429a396a-ac3a-46d2-8a17-cc79e28e32d5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"dengue virus","subitem_subject_scheme":"Other"},{"subitem_subject":"dengue serotypes","subitem_subject_scheme":"Other"},{"subitem_subject":"dengue outbreak 2022","subitem_subject_scheme":"Other"},{"subitem_subject":"multiple serotypes","subitem_subject_scheme":"Other"},{"subitem_subject":"Nepal","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Co-Circulation of Dengue Virus Serotypes 1, 2, and 3 during the 2022 Dengue Outbreak in Nepal: A Cross-Sectional Study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Co-Circulation of Dengue Virus Serotypes 1, 2, and 3 during the 2022 Dengue Outbreak in Nepal: A Cross-Sectional Study"}]},"item_type_id":"2","owner":"6","path":["36"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-03-06"},"publish_date":"2023-03-06","publish_status":"0","recid":"27938","relation_version_is_last":true,"title":["Co-Circulation of Dengue Virus Serotypes 1, 2, and 3 during the 2022 Dengue Outbreak in Nepal: A Cross-Sectional Study"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-05-15T18:12:27.013214+00:00"}