{"created":"2023-05-15T16:50:14.656423+00:00","id":28022,"links":{},"metadata":{"_buckets":{"deposit":"2d9d5902-4256-448c-9159-a7d8875da46a"},"_deposit":{"created_by":6,"id":"28022","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"28022"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00028022","sets":["10:11"]},"author_link":["125000","125001","124996","124998","124995","124997","124999"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-02-20","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"109913","bibliographicVolumeNumber":"117","bibliographic_titles":[{"bibliographic_title":"International Immunopharmacology"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The tumor microenvironment (TME), largely composed of tumor-associated macrophages (TAMs) and cancer-associated fibroblasts (CAFs), plays a key role in cancer progression. A small molecule, differentiation-inducing factor-1 (DIF-1) secreted by Dictyostelium discoideum, is known to exhibit anticancer activity; however, its effect on the TME remains unknown. In this study, we investigated the effect of DIF-1 on the TME using mouse triple-negative breast cancer 4T1-GFP cells, mouse macrophage RAW 264.7 cells, and mouse primary dermal fibroblasts (DFBs). Polarization of 4T1 cell-conditioned medium-induced macrophage into TAMs was not affected by DIF-1. In contrast, DIF-1 decreased 4T1 cell co-culturing-induced C-X-C motif chemokine ligand 1 (CXCL1), CXCL5, and CXCL7 expression in DFBs and suppressed DFB differentiation into CAF-like cells. Additionally, DIF-1 inhibited C-X-C motif chemokine receptor 2 (CXCR2) expression in 4T1 cells. Immunohistochemical analyses of tumor tissue samples excised from breast cancer-bearing mice showed that DIF-1 did not affect the number of CD206-positive TAMs; however, it decreased the number of α-smooth muscle actin-positive CAFs and CXCR2 expression. These results indicated that the anticancer effect of DIF-1 was partially attributed to the inhibition of CXCLs/CXCR2 axis-mediated communication between breast cancer cells and CAFs.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"International Immunopharmacology, 117, art. no. 109913; 2023　","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier B.V."}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.intimp.2023.109913","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"ⓒ 2023 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"15675769","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Seto-Tetsuo, Fumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Arioka, Masaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miura, Koichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Inoue, Takeru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Igawa, Kazunobu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tomooka, Katsuhiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sasaguri, Toshiyuki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2024-02-20"}],"displaytype":"detail","filename":"II117_109913.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"II117_109913.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/28022/files/II117_109913.pdf"},"version_id":"5d7a6e03-f08f-4944-93df-8897bbd3adcf"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Cancer-associated fibroblast","subitem_subject_scheme":"Other"},{"subitem_subject":"C-X-C type chemokine ligand","subitem_subject_scheme":"Other"},{"subitem_subject":"C-X-C type chemokine receptor 2D","subitem_subject_scheme":"Other"},{"subitem_subject":"ifferentiation-inducing factor-1","subitem_subject_scheme":"Other"},{"subitem_subject":"Tumor-associated macrophage","subitem_subject_scheme":"Other"},{"subitem_subject":"Tumor microenvironment","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"DIF-1 exhibits anticancer activity in breast cancer via inhibition of CXCLs/CXCR2 axis-mediated communication between cancer-associated fibroblasts and cancer cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"DIF-1 exhibits anticancer activity in breast cancer via inhibition of CXCLs/CXCR2 axis-mediated communication between cancer-associated fibroblasts and cancer cells"}]},"item_type_id":"2","owner":"6","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-03-30"},"publish_date":"2023-03-30","publish_status":"0","recid":"28022","relation_version_is_last":true,"title":["DIF-1 exhibits anticancer activity in breast cancer via inhibition of CXCLs/CXCR2 axis-mediated communication between cancer-associated fibroblasts and cancer cells"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-05-15T18:09:15.461285+00:00"}