{"created":"2023-05-15T16:50:16.360203+00:00","id":28061,"links":{},"metadata":{"_buckets":{"deposit":"94d675bc-fb54-4344-a2ac-44904e56df68"},"_deposit":{"created_by":6,"id":"28061","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"28061"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00028061","sets":["8:9"]},"author_link":["125210","125209","125205","125212","125203","125211","125213","125207","125208","125206","125204"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-01-27","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"164","bibliographicPageStart":"157","bibliographicVolumeNumber":"72","bibliographic_titles":[{"bibliographic_title":"Journal of Clinical Biochemistry and Nutrition"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"It is well known that oxidative stress causes certain diseases and organ damage. However, roles of oxidative stress in the acute phase of critical patients remain to be elucidated. This study aimed to investigate the balance of oxidative and antioxidative system and to clarify the association between oxidative stress and mortality in critically ill patients. This cohort study enrolled 247 patients transported to our emergency department by ambulance. Blood was drawn on hospital arrival, and serum derivatives of reactive oxidant metabolites (dROMs, oxidative index) and biological antioxidant potential (BAP, antioxidative index) were measured. Modified ratio (MR) is also calculated as BAP/dROMs/7.51. There were 197 survivors and 50 non-survivors. In the non-survivors, dROMs were significantly lower (274 vs 311, p<0.01), BAP was significantly higher (2,853 vs 2,138, p<0.01), and MR was significantly higher (1.51 vs 0.92, p<0.01) compared to those in the survivors. The AUC of MR was similar to that for the APACHE II score. Contrary to our expectations, higher BAP and lower dROMs were observed on admission in non-survivors. This may suggest that the antioxidative system is more dominant in the acute phase of severe insults and that the balance toward a higher antioxidative system is associated with mortality.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Journal of Clinical Biochemistry and Nutrition, 72(2), pp.157-164; 2023　","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The Society for Free Radical Research Japan"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3164/jcbn.22-79","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"©2023 JCBN. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/)."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0912-0009","subitem_source_identifier_type":"ISSN"}]},"item_2_text_62":{"attribute_name":"出版者別言語","attribute_value_mlt":[{"subitem_text_value":"日本酸化ストレス学会"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Izumino, Hiroo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tajima, Goro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tasaki, Osamu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Inokuma, Takamitsu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hatachi, Go"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takagi, Katsunori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyazaki, Takuro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsumoto, Keitaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsuchiya, Tomoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Shuntaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagayasu, Takeshi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-04-04"}],"displaytype":"detail","filename":"JCBN72_157.pdf","filesize":[{"value":"626.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JCBN72_157.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/28061/files/JCBN72_157.pdf"},"version_id":"4d04342b-b15e-4dd4-8141-a8749971be04"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"oxidative stress","subitem_subject_scheme":"Other"},{"subitem_subject":"critically ill patients","subitem_subject_scheme":"Other"},{"subitem_subject":"biological antioxidant potential","subitem_subject_scheme":"Other"},{"subitem_subject":"modified ratio","subitem_subject_scheme":"Other"},{"subitem_subject":"mortality","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Balance of the prooxidant and antioxidant system is associated with mortality in critically ill patients","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Balance of the prooxidant and antioxidant system is associated with mortality in critically ill patients"}]},"item_type_id":"2","owner":"6","path":["9"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-04-04"},"publish_date":"2023-04-04","publish_status":"0","recid":"28061","relation_version_is_last":true,"title":["Balance of the prooxidant and antioxidant system is associated with mortality in critically ill patients"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-05-15T18:07:36.341656+00:00"}