{"created":"2023-05-15T16:50:22.590489+00:00","id":28205,"links":{},"metadata":{"_buckets":{"deposit":"180fea6c-eb78-4661-9211-b15f2d4df106"},"_deposit":{"created_by":6,"id":"28205","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"28205"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00028205","sets":["10:22:24"]},"author_link":["125566","125561"],"item_5_alternative_title_19":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"血清反応陰性患者における免疫介在性重症筋無力症診断のための運動終板の解析"}]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-03-01","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"120494","bibliographicVolumeNumber":"443","bibliographic_titles":[{"bibliographic_title":"Journal of the Neurological Sciences"}]}]},"item_5_date_granted_64":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-03-01"}]},"item_5_degree_grantor_62":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"Nagasaki University (長崎大学)"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17301","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_61":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"This study aimed to evaluate the diagnostic usefulness of motor end-plate (MEP) analysis along with clustered acetylcholine receptor (AChR) antibody (Ab) assays in patients with myasthenia-like symptoms but negative routine AChR and muscle-specific kinase (MuSK) Ab tests. MEP analysis of muscle biopsies of the biceps brachii was performed in 20 patients to try to differentiate between those with or without immune-mediated myasthenia gravis (MG). Using a quantitative method, complement C3 deposition and AChR densities in MEPs were examined. Independently, cell-based assays were used to detect serum clustered-AChR Abs. Only five of 20 patients had complement deposition at MEPs; four of these patients had reduced AChR densities similar to those in patients with typical AChR Ab positive MG, and distinct from those in the remaining 15 patients. Two of the four serum samples from these patients had clustered-AChR Abs. All complement-positive patients were considered as having immune-mediated MG and improved with appropriate treatments; although one patient presented with MG 3 years later, the remaining patients had other diagnoses during over 10 years of follow-up. These results suggest the usefulness of MEP analysis of muscle biopsies in diagnosing immune-mediated MG in seronegative patients with myasthenia-like symptoms but, due to the invasiveness of the muscle biopsy procedure, clustered AChR Abs should, if possible, be tested first.","subitem_description_type":"Abstract"}]},"item_5_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"長崎大学学位論文 学位記番号:博(医歯薬)甲第1499号 学位授与年月日:令和5年3月1日","subitem_description_type":"Other"},{"subitem_description":"Author: Atsushi Nagaoka, Akira Tsujino, Hirokazu Shiraishi, Tadashi Kanamoto, Tomoaki Shima, Shunsuke Yoshimura, Teiichiro Miyazaki, Yohei Tateishi, Mitsuhiro Tsujihata, Masakatsu Motomura, Susan Maxwell, Osamu Higuchi, David Beeson, Angela Vincent","subitem_description_type":"Other"},{"subitem_description":"Citation: Journal of the Neurological Sciences, 443, art. no. 120494; 2022","subitem_description_type":"Other"}]},"item_5_description_69":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Nagasaki University (長崎大学), 博士(医学) (2023-03-01)","subitem_description_type":"Other"}]},"item_5_dissertation_number_65":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲医歯薬第1499号"}]},"item_5_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"125566","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Nagaoka, Atsushi"}]}]},"item_5_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier B.V."}]},"item_5_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.jns.2022.120494","subitem_relation_type_select":"DOI"}}]},"item_5_relation_42":{"attribute_name":"関係URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://hdl.handle.net/10069/00042232","subitem_relation_type_select":"HDL"}}]},"item_5_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2022 Elsevier B.V. All rights reserved."}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022510X","subitem_source_identifier_type":"ISSN"}]},"item_5_text_67":{"attribute_name":"学位の種類","attribute_value_mlt":[{"subitem_text_value":"課程博士"}]},"item_5_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"長岡, 篤志"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-04-25"}],"displaytype":"detail","filename":"ISYK1499_Nagaoka.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ISYK1499_Nagaoka.pdf","objectType":"fulltext","url":"https://nagasaki-u.repo.nii.ac.jp/record/28205/files/ISYK1499_Nagaoka.pdf"},"version_id":"8571afc7-6680-469b-b61d-9b008cdae9ae"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Myasthenia gravis","subitem_subject_scheme":"Other"},{"subitem_subject":"Motor end-plate","subitem_subject_scheme":"Other"},{"subitem_subject":"Complement","subitem_subject_scheme":"Other"},{"subitem_subject":"Clustered AChR antibody","subitem_subject_scheme":"Other"},{"subitem_subject":"Seronegative","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Motor end-plate analysis to diagnose immune-mediated myasthenia gravis in seronegative patients","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Motor end-plate analysis to diagnose immune-mediated myasthenia gravis in seronegative patients","subitem_title_language":"en"}]},"item_type_id":"5","owner":"6","path":["24"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-04-25"},"publish_date":"2023-04-25","publish_status":"0","recid":"28205","relation_version_is_last":true,"title":["Motor end-plate analysis to diagnose immune-mediated myasthenia gravis in seronegative patients"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-08-23T04:54:06.335711+00:00"}