@article{oai:nagasaki-u.repo.nii.ac.jp:00000029,
 author = {Thi, Aye Myat and Lee, Nathaniel and Parris, Victoria and Marin, Flora P and Roy, Lynsil and Calapis, Rugaiya W and Ariyoshi, Koya and Parry, Christopher M and Cox, Sharon E},
 issue = {9},
 journal = {Transactions of The Royal Society of Tropical Medicine and Hygiene},
 month = {Jun},
 note = {BACKGROUND: The Philippines is a high TB and multidrug-resistant TB burden country. Although the scale-up of GeneXpert testing 
is occurring, the benefits of universal Xpert-Mycobacterium tuberculosis/ rifampicin (MTB/RIF) testing in inpatients have not
 been documented. METHODS: Routine GeneXpert testing irrespective of priority criteria for testing was conducted within 
a prospective cohort of all adults with known or presumptive TB admitted to a tertiary infectious diseases hospital in Manila. Study-specific TB diagnosis was decided upon bacteriological results, chest x-ray assessment, if already on anti-TB treatment (ATT) at admission and a cough duration of ?2 wk. RESULTS: Of submitted sputum samples, 87.1% (277/318) had valid acid-fast bacilli (AFB) microscopy and XpertR MTB/RIF results. XpertR MTB/RIF was positive in 97.7% (n = 87/89) of AFB-positive patients and 25.5% (n = 48/188) of AFB-negative patients. Bacteriological confirmation in smear negative cases not on ATT prior to admission was 25.2% (34/135). Rifampicin resistance was detected in 26/135 Xpert positive cases (19.3%), including nine 
who might not otherwise have been detected, representing a 53% increase in yield. CONCLUSION: Universal GeneXpert testing 
in this setting enhanced the yield of bacterial confirmation, revealing a high incidence of rifampicin resistance and suggesting a need for further investigations in Xpert-negative/smear-positive patients who may not have mycobacterial TB., Transactions of the Royal Society of Tropical Medicine and Hygiene, 114(9), pp.682-686; 2020},
 pages = {682--686},
 title = {An observational report of universal GeneXpert testing of inpatients with diagnosed or presumptive TB in the Philippines},
 volume = {114},
 year = {2020}
}