{"created":"2023-05-15T16:31:31.378209+00:00","id":2982,"links":{},"metadata":{"_buckets":{"deposit":"4e2dd399-5185-49a7-b4b2-fbef5941ed11"},"_deposit":{"created_by":2,"id":"2982","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"2982"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00002982","sets":["29:30"]},"author_link":["13372","13374","13375","13373"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-04-06","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"9","bibliographicVolumeNumber":"37","bibliographic_titles":[{"bibliographic_title":"Journal of Physiological Anthropology"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"BACKGROUND: Recent studies have explored various genetic and physiological factors related to high-altitude adaptation in highlander populations. However, the effects of single nucleotide polymorphisms (SNPs), influencing such adaptation, on physiological responses to hypobaric hypoxia have not been examined in lowlanders with lowlander ancestry. Thus, we aimed to investigate the association between SNPs around the EGLN1 genomic region, possibly involved in high-altitude adaptation, and physiological changes to hypobaric hypoxia exposure in a cohort of Japanese lowlanders.\nMETHODS: Physiological data were obtained from 46 healthy Japanese male students under different atmospheric pressure conditions (equivalent to sea level and altitudes of 2500 and 4000 m). Genotypes of seven SNPs around EGLN1 were determined in all subjects by PCR-direct sequencing or TaqMan SNP genotyping assay.\nRESULTS: Results of the association study suggest that percutaneous arterial oxygen saturation (SpO2) responses of individuals with rs12097901 and rs2790859 alleles, whose frequencies are high in highlander populations (HL alleles), may be susceptible to acute hypobaric hypoxia. SpO2 levels of individuals with HL alleles were lower than those of individuals with non-HL alleles. At the same time, the subjects with HL alleles did not appear to have any remarkable hematological or pulmonary features that may counteract the low levels of SpO2. One may hypothesize that the low SpO2 levels in HL allele carriers could be a risk factor for acute mountain sickness in Japanese population.\nCONCLUSIONS: Our findings suggest that rs12097901 and rs2790859 genotypes affect SpO2 responses and may be associated with the susceptibility to acute hypobaric hypoxia in Japanese population.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Journal of Physiological Anthropology, 37, 9; 2018","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本生理人類学会"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1186/s40101-018-0169-7","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and\nreproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver\n(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated."}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"18806805","subitem_source_identifier_type":"ISSN"}]},"item_2_text_62":{"attribute_name":"出版者別言語","attribute_value_mlt":[{"subitem_text_value":"Japan Society of Physiological Anthropology"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yasukochi, Yoshiki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishimura, Takayuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Motoi, Midori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Watanuki, Shigeki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"JPA37_9.pdf","filesize":[{"value":"933.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JPA37_9.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/2982/files/JPA37_9.pdf"},"version_id":"4dab26f4-55f7-4790-90da-750a81972a76"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"EGLN1","subitem_subject_scheme":"Other"},{"subitem_subject":"High-altitude adaptation","subitem_subject_scheme":"Other"},{"subitem_subject":"Hypobaric hypoxia","subitem_subject_scheme":"Other"},{"subitem_subject":"SNP","subitem_subject_scheme":"Other"},{"subitem_subject":"SpO2","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Association of EGLN1 genetic polymorphisms with SpO2 responses to acute hypobaric hypoxia in a Japanese cohort","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Association of EGLN1 genetic polymorphisms with SpO2 responses to acute hypobaric hypoxia in a Japanese cohort"}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-05-29"},"publish_date":"2018-05-29","publish_status":"0","recid":"2982","relation_version_is_last":true,"title":["Association of EGLN1 genetic polymorphisms with SpO2 responses to acute hypobaric hypoxia in a Japanese cohort"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:38:17.965200+00:00"}