{"created":"2023-05-15T16:31:31.421149+00:00","id":2983,"links":{},"metadata":{"_buckets":{"deposit":"35c59cc1-a454-4e4a-9003-39b4df5ddb01"},"_deposit":{"created_by":2,"id":"2983","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"2983"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00002983","sets":["35:36"]},"author_link":["13378","13377","13379","13376","13380","13382","13381"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-04-17","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"169","bibliographicVolumeNumber":"17","bibliographic_titles":[{"bibliographic_title":"Malaria Journal"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Alterations in inflammatory cytokines and genetic background of the host contribute to the outcome of malaria infection. Despite the promising protective role of IL-17 in infections, little attention is given to further understand its importance in the pathogenesis of severe malaria anaemia in chronic/endemic situations. The objective of this study, therefore, was to evaluate IL-17 levels in anaemic condition and its association with host genetic factors. Methods: Two mice strains (Balb/c and CBA) were crossed to get the F1 progeny, and were (F1, Balb/c, CBA) taken through 6 cycles of Plasmodium berghei (ANKA strain) infection and chloroquine/pyrimethamine treatment to generate semi-immune status. Cytokine levels and kinetics of antibody production, CD4+CD25+T regulatory cells were evaluated by bead-based multiplex assay kit, ELISA and FACs, respectively. Results: High survival with high Hb loss at significantly low parasitaemia was observed in Balb/c and F1. Furthermore, IgG levels were two times higher in Balb/c, F1 than CBA. While CD4+CD25+ Treg cells were lower in CBA; IL-4, IFN-γ, IL-12α and IL-17 were significantly higher (p < 0.05) in Balb/c, F1. Conclusions: In conclusion, elevated IL-17 levels together with high IL-4, IL-12α and IFN-γ levels may be a marker of protection, and the mechanism may be controlled by host factor (s). Further studies of F2 between the F1 and Balb/c will be informative in evaluating if these genes are segregated or further apart.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Malaria Journal, 17, 169; 2018","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"BioMed Central Ltd."}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1186/s12936-018-2257-x","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creat iveco mmons .org/licen ses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium,\nprovided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creat iveco mmons .org/publi cdoma in/zero/1.0/) applies to the data made available in this article, unless otherwise stated."}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"14752875","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Helegbe, Gideon Kofi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Huy, Nguyen Tien"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yanagi, Tetsuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shuaibu, Mohammed Nasir"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kikuchi, Mihoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Cherif, Mahamoud Sama"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hirayama, Kenji"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"MalJou17_169.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"MalJou17_169.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/2983/files/MalJou17_169.pdf"},"version_id":"8a4a9a1c-3751-4e07-a93e-65fce6c78d5b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Anaemia","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-17","subitem_subject_scheme":"Other"},{"subitem_subject":"Plasmodium berghei ANKA","subitem_subject_scheme":"Other"},{"subitem_subject":"Semi-immune mice","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Elevated IL-17 levels in semi-immune anaemic mice infected with Plasmodium berghei ANKA","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Elevated IL-17 levels in semi-immune anaemic mice infected with Plasmodium berghei ANKA"}]},"item_type_id":"2","owner":"2","path":["36"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-05-29"},"publish_date":"2018-05-29","publish_status":"0","recid":"2983","relation_version_is_last":true,"title":["Elevated IL-17 levels in semi-immune anaemic mice infected with Plasmodium berghei ANKA"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:38:16.259175+00:00"}