{"created":"2023-05-15T16:31:32.546405+00:00","id":3009,"links":{},"metadata":{"_buckets":{"deposit":"fed0ec80-10d7-4c51-bb49-e446b7118a92"},"_deposit":{"created_by":2,"id":"3009","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"3009"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00003009","sets":["29:30"]},"author_link":["13565","13574","13566","13575","13568","13572","13578","13570","13563","13576","13564","13577","13567","13569","13573","13571"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-03-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"44","bibliographicVolumeNumber":"18","bibliographic_titles":[{"bibliographic_title":"BMC Pulmonary Medicine"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Interstitial lung disease (ILD) is a prognostic indicator of poor outcome in myositis. Although the pathogenesis of myositis-associated ILD is not well understood, neutrophils are thought to play a pivotal role. Neutrophils store azurophil granules that contain defensins, which are antimicrobial peptides that regulate the inflammatory response. Here, we evaluated levels of the human neutrophil peptides (HNPs) α-defensin 1 through 3 in patients with myositis-associated ILD to determine whether HNPs represent disease markers and play a role in the pathogenesis of myositis-associated ILD. Methods: HNP levels were measured in the plasma and bronchoalveolar lavage fluid (BALF) of 56 patients with myositis-associated ILD and 24 healthy controls by enzyme-linked immunosorbent assay. Results: Analysis revealed significantly higher HNP levels in plasma and BALF samples from patients with myositis-associated ILD as compared to those of healthy controls; however, plasma HNPs were significantly correlated with total cell counts in BALF. Additionally, BALF HNP levels were positively correlated with serum surfactant protein-A and the percentage of neutrophils in BALF, and BALF HNP levels correlated with the percentage of reticular opacities in high-resolution computed tomography results for patients with anti-aminoacyl-tRNA synthetase (ARS) antibody positive myositis-associated ILD. Survival did not differ between patients with higher and lower levels of plasma and BALF HNPs. Conclusions: Plasma and BALF HNPs might reflect the disease activities of myositis-associated ILD, especially in patients with anti-ARS antibody positive myositis-associated ILD. However further studies are necessary to clarify whether HNPs represent disease markers and play roles in disease pathogenesis.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"BMC Pulmonary Medicine, 18(1), 44; 2018","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"BioMed Central Ltd."}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1186/s12890-018-0609-5","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2018 The Author(s). This article is distributed under the terms of the Creative Commons Attribution 4.0International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, andreproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link tothe Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver \n(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated."}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"14712466","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sakamoto, Noriho"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishimoto, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kakugawa, Tomoyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Satoh, Minoru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hasegawa, Tomoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanaka, Shin"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hara, Atsuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakashima, Shota"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yura, Hirokazu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyamura, Takuto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Koyama, Hanako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Morita, Towako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamichi, Seiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Obase, Yasushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishimatsu, Yuji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mukae, Hiroshi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"BMCPM18_44.pdf","filesize":[{"value":"751.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"BMCPM18_44.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/3009/files/BMCPM18_44.pdf"},"version_id":"cf4ae18f-6c16-48e8-bdaf-307745d70101"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Bronchoalveolar lavage fluid","subitem_subject_scheme":"Other"},{"subitem_subject":"Human neutrophil peptide","subitem_subject_scheme":"Other"},{"subitem_subject":"Idiopathic inflammatory myopathies","subitem_subject_scheme":"Other"},{"subitem_subject":"Interstitial lung disease","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Elevated α-defensin levels in plasma and bronchoalveolar lavage fluid from patients with myositis-associated interstitial lung disease","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Elevated α-defensin levels in plasma and bronchoalveolar lavage fluid from patients with myositis-associated interstitial lung disease"}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-05"},"publish_date":"2018-06-05","publish_status":"0","recid":"3009","relation_version_is_last":true,"title":["Elevated α-defensin levels in plasma and bronchoalveolar lavage fluid from patients with myositis-associated interstitial lung disease"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:37:49.544307+00:00"}