@phdthesis{oai:nagasaki-u.repo.nii.ac.jp:00003114,
 author = {原口, 愛},
 month = {Mar},
 note = {Objective: This study investigated the relationship between aortic 18F-fluoro-2-deoxy-D-glucose (18F-FDG) uptake and clinical and laboratory findings related to atherosclerosis in a general population. Methods: 18F-FDG uptake in the ascending aorta was measured on the positron emission tomography/computed tomography (PET/CT) scans of 211 Japanese adults. The maximum target-to-background ratio (TBR) was compared with clinical and laboratory atherosclerosis findings. Results: By multivariate regression analysis adjusted for age and sex, TBR-ascending aorta (TBR-A) was significantly correlated with various clinical and laboratory parameters, such as body mass index, log visceral fat area, low-density lipoprotein cholesterol (LDL-C), log fasting immunoreactive insulin, log homeostasis model assessment of insulin resistance, log total adiponectin and log-leptin, in all subjects. Furthermore, by multivariate linear regression analysis adjusted for confounding factors, TBR-A was significantly correlated with LDL-C (b = 0.001, p = 0.03) and log-leptin (b = 0.336, p,0.01) in all subjects. Conclusion: TBR-A was significantly correlated with LDL-C and log-leptin independent from confounding factors. Our results suggest that aortic 18F-FDG uptake is a good marker of atherosclerosis, even in a general population., 長崎大学学位論文 学位記番号:博(医歯薬)甲第831号 学位授与年月日:平成28年3月18日, Author: Ai Haraguchi, Naomi Hayashida, Toshihiko Kamasaki, Izumi Miyamoto, Toshiya Usui, Takao Ando, Norio Abiru, Hironori Yamasaki, Kenya Chiba, Takashi Kudo, Atsushi Kawakami, Noboru Takamura, Citation: PLoS ONE, 9(11), e111990; 2014, Nagasaki University (長崎大学), 博士(医学) (2016-03-18)},
 school = {Nagasaki University (長崎大学)},
 title = {Uptake of Aortic 18F-FDG Is Correlated with Low-Density Lipoprotein Cholesterol and Leptin in a General Population},
 year = {2016}
}