{"created":"2023-05-15T16:31:39.018535+00:00","id":3160,"links":{},"metadata":{"_buckets":{"deposit":"44dd4569-67cf-4c5b-be7e-480c16220b89"},"_deposit":{"created_by":6,"id":"3160","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"3160"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00003160","sets":["10:22:24"]},"author_link":["115271","115270"],"item_5_alternative_title_19":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"マラリア原虫感染におけるCD４＋T細胞のPD-1／LAG-3発現とサイトカイン産生の解析"}]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-03-18","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"131","bibliographicPageStart":"121","bibliographicVolumeNumber":"60","bibliographic_titles":[{"bibliographic_title":"Microbiology and Immunology"}]}]},"item_5_date_granted_64":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2016-03-18"}]},"item_5_degree_grantor_62":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"Nagasaki University (長崎大学)"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17301","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_61":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"CD4+ T cells play critical roles in protection against the blood-stage of malaria infection, but their uncontrolled activation can be harmful to the host. We compared the expression of inhibitory receptors on activated CD4+ T cells and their cytokine production using rodent models of Plasmodium parasites, and compared them with those from a bacterial and another protozoan infection. CD4+ T cells from mice infected with P. yoelii 17XL, P yoelii 17XNL, P. chabaudi, P. vinckei, and P. berghei expressed the inhibitory receptors, PD-1 and LAG-3 as early as 6 days after infection, while those from either Listeria monocytogenes or Leishmania major-infected mice did not. In response to T-cell receptor stimulation, CD4+ T cells from mice infected with all the pathogens under study produced high levels of IFN-γ. IL-2 production was reduced in mice infected with Plasmodium species, but not with Listeria or Leishmania. In vitro blockade of the interaction between PD-1 and its ligands resulted in increased IFN-γ production in response to Plasmodium antigens, implying that PD-1 expressed on activated CD4+ T cells actively inhibit T cell immune responses. Studies using Myd88-/-, Trif-/-, and Irf3-/- mice showed that the induction of these CD4+ T cells and their ability to produce cytokines was largely independent of toll-like receptor signaling. These studies suggest that the expression of the inhibitory receptors, PD-1 and LAG-3 on CD4+ T cells and their reduced IL-2 production are common characteristic features of Plasmodium infection.","subitem_description_type":"Abstract"}]},"item_5_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"長崎大学学位論文 学位記番号:博(医歯薬)甲第859号 学位授与年月日:平成28年3月18日","subitem_description_type":"Other"},{"subitem_description":"Author: Henrietta T. Doe, Daisuke Kimura, Mana Miyakoda, Kazumi Kimura, Masoud Akbari, Katsuyuki Yui","subitem_description_type":"Other"},{"subitem_description":"Citation: Microbiology and Immunology, 60(2), pp.121-131; 2016","subitem_description_type":"Other"}]},"item_5_description_69":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Nagasaki University (長崎大学), 博士(医学) (2016-03-18)","subitem_description_type":"Other"}]},"item_5_dissertation_number_65":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲医歯薬第859号"}]},"item_5_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"115271","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ドー, ヘンリータ　テーコ"}]}]},"item_5_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"John Wiley & Sons Australia, Ltd"}]},"item_5_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/1348-0421.12354","subitem_relation_type_select":"DOI"}}]},"item_5_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(C) 2015 the Japanese Society for Bacteriology, the Japanese Society for Virology, the Japanese Society for Host Defense Research, and John Wiley & Sons Australia, Ltd."},{"subitem_rights":"This is the peer reviewed version of the following article: Microbiology and Immunology, 60(2), pp.121-131; 2016, which has been published in final form at http://dx.doi.org/10.1111/1348-0421.12354. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03855600","subitem_source_identifier_type":"ISSN"}]},"item_5_text_67":{"attribute_name":"学位の種類","attribute_value_mlt":[{"subitem_text_value":"課程博士"}]},"item_5_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Doe, Henrietta Terko"}],"nameIdentifiers":[{"nameIdentifier":"115270","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-02-01"}],"displaytype":"detail","filename":"ISYK859_Doe.pdf","filesize":[{"value":"742.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ISYK859_Doe.pdf","objectType":"fulltext","url":"https://nagasaki-u.repo.nii.ac.jp/record/3160/files/ISYK859_Doe.pdf"},"version_id":"71f87d82-577c-49c6-96ff-5f0581854d3e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"malaria","subitem_subject_scheme":"Other"},{"subitem_subject":"CD4+ T cells","subitem_subject_scheme":"Other"},{"subitem_subject":"inhibitory receptor","subitem_subject_scheme":"Other"},{"subitem_subject":"cytokines","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Expression of PD-1/LAG-3 and cytokine production by CD4+T cells during infection with Plasmodiumparasites","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Expression of PD-1/LAG-3 and cytokine production by CD4+T cells during infection with Plasmodiumparasites","subitem_title_language":"en"}]},"item_type_id":"5","owner":"6","path":["24"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-03-01"},"publish_date":"2017-03-01","publish_status":"0","recid":"3160","relation_version_is_last":true,"title":["Expression of PD-1/LAG-3 and cytokine production by CD4+T cells during infection with Plasmodiumparasites"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-08-23T05:00:05.460625+00:00"}