@article{oai:nagasaki-u.repo.nii.ac.jp:00000352,
 author = {Fukuda, Tsutomu and Matsuoka, Fuyuki and Matsuo, Yuri and Yoshioka, Naoki and Onodera, Gen and Kimura, Masanari and Ishibashi, Fumito and Iwao, Masatomo},
 issue = {2},
 journal = {HETEROCYCLES},
 month = {Dec},
 note = {Novel topoisomerase I inhibitors possessing the 5,13-dihydro- 6H-benzo[6,7]indolo[3,2-c]quinolin-6-one (BIQ) scaffold were designed and synthesized. This scaffold was constructed using sequential and regioselective functionalization of the pyrrole core through palladium-catalyzed cross-coupling, conventional electrophilic substitution, directed lithiation, and subsequent diphenylphosphoryl azide (DPPA)-mediated lactam ring construction. The obtained BIQs were evaluated for their topoisomerase I inhibitory activities and their antiproliferative activities in the panel of 39 human cancer cell lines established by the Japanese Foundation for Cancer Research (JFCR39)., HETEROCYCLES, 99(2), pp.1032?1052; 2019},
 pages = {1032--1052},
 title = {Synthesis and Evaluation of Topoisomerase I Inhibitors Possessing the 5,13-Dihydro-6H-benzo[6,7]indolo[3,2-c]quinolin-6-one Scaffold},
 volume = {99},
 year = {2018}
}