{"created":"2023-05-15T16:29:33.628169+00:00","id":352,"links":{},"metadata":{"_buckets":{"deposit":"c4f675e5-1f24-4659-871d-206e5f721555"},"_deposit":{"created_by":2,"id":"352","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"352"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00000352","sets":["14:21"]},"author_link":["1700","1703","1706","1702","1701","1704","1705","1699"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-12-19","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"1052","bibliographicPageStart":"1032","bibliographicVolumeNumber":"99","bibliographic_titles":[{"bibliographic_title":"HETEROCYCLES"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Novel topoisomerase I inhibitors possessing the 5,13-dihydro- 6H-benzo[6,7]indolo[3,2-c]quinolin-6-one (BIQ) scaffold were designed and synthesized. This scaffold was constructed using sequential and regioselective functionalization of the pyrrole core through palladium-catalyzed cross-coupling, conventional electrophilic substitution, directed lithiation, and subsequent diphenylphosphoryl azide (DPPA)-mediated lactam ring construction. The obtained BIQs were evaluated for their topoisomerase I inhibitory activities and their antiproliferative activities in the panel of 39 human cancer cell lines established by the Japanese Foundation for Cancer Research (JFCR39).","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"HETEROCYCLES, 99(2), pp.1032?1052; 2019","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本複素環化学研究所"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3987/COM-18-S(F)70","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2019 The Japan Institute of Heterocyclic Chemistry"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03855414","subitem_source_identifier_type":"ISSN"}]},"item_2_text_62":{"attribute_name":"出版者別言語","attribute_value_mlt":[{"subitem_text_value":"Japan Institute of Heterocyclic Chemistry"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Fukuda, Tsutomu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuoka, Fuyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuo, Yuri"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshioka, Naoki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Onodera, Gen"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kimura, Masanari"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishibashi, Fumito"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iwao, Masatomo"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-18"}],"displaytype":"detail","filename":"Het99_1032_SI.pdf","filesize":[{"value":"5.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Het99_1032_SI.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/352/files/Het99_1032_SI.pdf"},"version_id":"f8180692-a17d-4e6b-9375-b039a122d502"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-18"}],"displaytype":"detail","filename":"Het99_1032.pdf","filesize":[{"value":"1.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Het99_1032.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/352/files/Het99_1032.pdf"},"version_id":"bdc13a1b-682d-4046-8e48-fe5c4db3dac1"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Synthesis and Evaluation of Topoisomerase I Inhibitors Possessing the 5,13-Dihydro-6H-benzo[6,7]indolo[3,2-c]quinolin-6-one Scaffold","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Synthesis and Evaluation of Topoisomerase I Inhibitors Possessing the 5,13-Dihydro-6H-benzo[6,7]indolo[3,2-c]quinolin-6-one Scaffold"}]},"item_type_id":"2","owner":"2","path":["21"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-11-05"},"publish_date":"2019-11-05","publish_status":"0","recid":"352","relation_version_is_last":true,"title":["Synthesis and Evaluation of Topoisomerase I Inhibitors Possessing the 5,13-Dihydro-6H-benzo[6,7]indolo[3,2-c]quinolin-6-one Scaffold"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:18:14.204325+00:00"}