{"created":"2023-05-15T16:29:33.875359+00:00","id":358,"links":{},"metadata":{"_buckets":{"deposit":"939651e5-587a-4a77-829d-e6d13ae40cb4"},"_deposit":{"created_by":2,"id":"358","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"358"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00000358","sets":["10:11"]},"author_link":["1740","1742","1734","1736","1738","1735","1739","1737","1741"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-10-19","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"101994","bibliographicVolumeNumber":"74","bibliographic_titles":[{"bibliographic_title":"Parasitology International"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"IL-27, a regulatory cytokine, plays critical roles in the prevention of immunopathology during Plasmodium infection. We examined these roles in the immune responses against Plasmodium chabaudi infection using the Il-27ra?/? mice. While IL-27 was expressed at high levels during the early phase of the infection, enhanced CD4+ T cell function and reduction in parasitemia were observed mainly during the chronic phase in the mutant mice. In mice infected with P. chabaudi and cured with drug, CD4+ T cells in the Il-27ra?/? mice exhibited enhanced CD4+ T-cell responses, indicating the inhibitory role of IL-27 on the protective immune responses. To determine the role of IL-27 in detail, we performed CD4+ T-cell transfer experiments. The Il-27ra?/? and Il27p28?/? mice were first infected with P. chabaudi and then cured using drug treatment. Plasmodium-antigen primed CD4+ T cells were prepared from these mice and transferred into the recipient mice, followed by infection with the heterologous parasite P. berghei ANKA. Il-27ra?/? CD4+ T cells in the infected recipient mice did not produce IL-10, indicating that IL-10 production by primed CD4+ T cells is IL-27 dependent. Il27p28?/? CD4+ T cells that were primed in the absence of IL-27 exhibited enhanced recall responses during the challenge infection with P. berghei ANKA, implying that IL-27 receptor signaling during the primary infection affects recall responses in the long-term via the regulation of the memory CD4+ T cell generation. These features highlighted direct and time-transcending roles of IL-27 in the regulation of immune responses against chronic infection with Plasmodium parasites.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Parasitology International, 74, art.no.101994; 2019","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier Ireland Ltd"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.parint.2019.101994","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2019 The Author(s) Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license(http://creativecommons.org/licenses/BY-NC-ND/4.0/)."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13835769","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sukhbaatar, Odsuren"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kimura, Daisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyakoda, Mana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamae, Sayuri"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kimura, Kazumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hara, Hiromitsu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshida, Hiroki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Inoue, Shin-Ichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yui, Katsuyuki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-18"}],"displaytype":"detail","filename":"ParaInt74_101994.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ParaInt74_101994.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/358/files/ParaInt74_101994.pdf"},"version_id":"e6a13854-d8f6-4ad3-a3b9-2d3478b95185"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Malaria","subitem_subject_scheme":"Other"},{"subitem_subject":"CD4+ T cells","subitem_subject_scheme":"Other"},{"subitem_subject":"Cytokine","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-27","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-10","subitem_subject_scheme":"Other"},{"subitem_subject":"Protective immunity","subitem_subject_scheme":"Other"},{"subitem_subject":"Immunological memory","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Activation and IL-10 production of specific CD4+ T cells are regulated by IL-27 during chronic infection with Plasmodium chabaudi","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Activation and IL-10 production of specific CD4+ T cells are regulated by IL-27 during chronic infection with Plasmodium chabaudi"}]},"item_type_id":"2","owner":"2","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-11-12"},"publish_date":"2019-11-12","publish_status":"0","recid":"358","relation_version_is_last":true,"title":["Activation and IL-10 production of specific CD4+ T cells are regulated by IL-27 during chronic infection with Plasmodium chabaudi"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:18:07.844654+00:00"}