{"created":"2023-05-15T16:32:03.389309+00:00","id":3726,"links":{},"metadata":{"_buckets":{"deposit":"4601e337-7330-489e-b660-428e8c65c56f"},"_deposit":{"created_by":2,"id":"3726","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"3726"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00003726","sets":["29:30"]},"author_link":["15152","15158","15165","15162","15154","15160","15156","15159","15163","15157","15164","15153","15155","15161"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-12-31","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4121","bibliographicPageStart":"4111","bibliographicVolumeNumber":"21","bibliographic_titles":[{"bibliographic_title":"Medical Science Monitor"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Refractory gastroesophageal reflux disease (GERD) may deteriorate patient quality of life (QOL) despite proton pump inhibitor (PPI) therapy. Material/Methods: Nineteen Japanese institutions were surveyed to determine the clinical characteristics and QOL of patients with refractory GERD. Those patients treated with a conventional PPI were switched to 20 mg esomeprazole for 4 weeks. Symptoms and QOL were assessed using Global Overall Symptom and Gastrointestinal Symptom Rating Scale (GSRS) questionnaires at baseline and at 2 and/or 4 weeks of esomeprazole treatment. Results: Of 120 patients who completed the survey, 58 (48.3%) had refractory GERD. Of these, 69.0% were aged >65 years, 79.3% were prescribed a PPI at a standard or high dose, and 22.4% were prescribed a PPI together with another drug. After switching to esomeprazole, patients reported significant improvements in heartburn, acid regurgitation, and excessive belching at 2 weeks using a symptom diary, as well as the total score, reflux, ab dominal pain, and indigestion, which were assessed using the GSRS at 4 weeks. Conclusions: About half of Japanese patients with GERD may be refractory to conventional PPIs. Their reflux-related symp toms are often severe and may impair QOL. Switching to esomeprazole could be used to improve their symptoms and QOL.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Medical Science Monitor, 21, pp.4111-4121; 2015","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"International Scientific Literature Inc."}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.12659/MSM.895346","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c Med Sci Monit, 2015"},{"subitem_rights":"This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License."}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"16433750","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takeshima, Fuminao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hashiguchi, Keiichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Onitsuka, Yasunori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanigawa, Ken"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Minami, Hitomi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsushima, Kayoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Akazawa, Yuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shiozawa, Ken"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamaguchi, Naoyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Taura, Naota"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohnita, Ken"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ichikawa, Tatsuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Isomoto, Hajime"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakao, Kazuhiko"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"MSM21_4111.pdf","filesize":[{"value":"288.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"MSM21_4111.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/3726/files/MSM21_4111.pdf"},"version_id":"b5fa1f80-dcbe-4bcf-8f9a-5209aa3b431a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Esomeprazole","subitem_subject_scheme":"Other"},{"subitem_subject":"Gastroesophageal Reflux","subitem_subject_scheme":"Other"},{"subitem_subject":"Proton Pump Inhibitors","subitem_subject_scheme":"Other"},{"subitem_subject":"Quality of Life","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Clinical Characteristics of Patients with Gastroesophageal Reflux Disease Refractory to Proton Pump Inhibitors and the Effects of Switching to 20 mg Esomeprazole on Reflux Symptoms and Quality of Life","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Clinical Characteristics of Patients with Gastroesophageal Reflux Disease Refractory to Proton Pump Inhibitors and the Effects of Switching to 20 mg Esomeprazole on Reflux Symptoms and Quality of Life"}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-10-27"},"publish_date":"2016-10-27","publish_status":"0","recid":"3726","relation_version_is_last":true,"title":["Clinical Characteristics of Patients with Gastroesophageal Reflux Disease Refractory to Proton Pump Inhibitors and the Effects of Switching to 20 mg Esomeprazole on Reflux Symptoms and Quality of Life"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:29:39.416627+00:00"}