{"created":"2023-05-15T16:32:03.475764+00:00","id":3728,"links":{},"metadata":{"_buckets":{"deposit":"67ff5844-dee4-4c8d-b8ec-2267dbf2976f"},"_deposit":{"created_by":2,"id":"3728","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"3728"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00003728","sets":["29:30"]},"author_link":["15183","15186","15185","15182","15184","15187","15181"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-11-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageStart":"e0142305","bibliographicVolumeNumber":"10","bibliographic_titles":[{"bibliographic_title":"PLOS ONE"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Acetylation of nucleosomal histones by diverse histone acetyltransferases (HAT) plays pivotal roles in many cellular events. Discoveries of novel HATs and HAT related factors have provided new insights to understand the roles and mechanisms of histone acetylation. In this study, we identified prominent Histone H3 acetylation activity in vitro and purified its activity, showing that it is composed of the MYST acetyltransferase Chameau and Enhancer of the Acetyltransferase Chameau (EAChm) family. EAChm is a negatively charged acidic protein retaining aspartate and glutamate. Furthermore, we identified that Chameau and EAChm stimulate transcription in vitro together with purified general transcription\nfactors. In addition, RNA-seq analysis of Chameu KD and EAChm KD S2 cells suggest that Chameau and EAChm regulate transcription of common genes in vivo. Our results suggest that EAChm regulates gene transcription in Drosophila embryos by enhancing\nAcetyltransferase Chameau activity.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"PLOS ONE, 10(11), e0142305; 2015","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Public Library of Science"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1371/journal.pone.0142305","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2015 Nakagawa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited."}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"19326203","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nakagawa, Takeya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ikehara, Tsuyoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Doiguchi, Masamichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Imamura, Yuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Higashi, Miki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoneda, Mitsuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ito, Takashi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"PLoS10_142305.pdf","filesize":[{"value":"3.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PLoS10_142305.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/3728/files/PLoS10_142305.pdf"},"version_id":"297eb535-9aef-42df-b899-33470f04b46c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Enhancer of Acetyltransferase Chameau (EAChm) Is a Novel Transcriptional Co-Activator","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Enhancer of Acetyltransferase Chameau (EAChm) Is a Novel Transcriptional Co-Activator"}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-10-27"},"publish_date":"2016-10-27","publish_status":"0","recid":"3728","relation_version_is_last":true,"title":["Enhancer of Acetyltransferase Chameau (EAChm) Is a Novel Transcriptional Co-Activator"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:29:36.495573+00:00"}