{"created":"2023-05-15T16:32:03.818771+00:00","id":3736,"links":{},"metadata":{"_buckets":{"deposit":"5e3247e0-4319-4ae2-b623-23c74bb40bb2"},"_deposit":{"created_by":2,"id":"3736","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"3736"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00003736","sets":["73:74"]},"author_link":["15239","15237","15238","15236"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-01-27","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"19913","bibliographicVolumeNumber":"6","bibliographic_titles":[{"bibliographic_title":"Scientific Reports"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A peptide composed of lysine with a guanidinylethyl (GEt) amine structure in the side chain [Lys(GEt)] was developed as a cell-penetrating peptide directed to plasmid DNA (pDNA) delivery. The GEt amine adopted a diprotonated form at neutral pH, which may have led to the more efficient cellular uptake of a Lys(GEt)-peptide than an arginine-peptide at a low concentration. Lys(GEt)-peptide/pDNA complexes showed the highest transfection efficiency due to efficient endosomal escape without any cytotoxicity. Lys(GEt)-peptide may be a promising candidate as a gene delivery carrier.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Scientific Reports, 6, 19913; 2016","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nature Publishing Group"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/srep19913","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"20452322","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Oba, Makoto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kato, Takuma"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Furukawa, Kaori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanaka, Masakazu"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"SciRep6_19913.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"SciRep6_19913.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/3736/files/SciRep6_19913.pdf"},"version_id":"7cd1a5f2-3df7-4aa8-97f4-a7b2fb4bc624"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A Cell-Penetrating Peptide with a Guanidinylethyl Amine Structure Directed to Gene Delivery","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A Cell-Penetrating Peptide with a Guanidinylethyl Amine Structure Directed to Gene Delivery"}]},"item_type_id":"2","owner":"2","path":["74"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-11-01"},"publish_date":"2016-11-01","publish_status":"0","recid":"3736","relation_version_is_last":true,"title":["A Cell-Penetrating Peptide with a Guanidinylethyl Amine Structure Directed to Gene Delivery"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:29:25.134467+00:00"}