{"created":"2023-05-15T16:32:04.467081+00:00","id":3751,"links":{},"metadata":{"_buckets":{"deposit":"3016afe7-1e01-4e03-9802-df2f600253fc"},"_deposit":{"created_by":2,"id":"3751","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"3751"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00003751","sets":["8:9"]},"author_link":["15326","15327","15330","15323","15325","15328","15324","15329"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"42","bibliographicPageStart":"37","bibliographicVolumeNumber":"14","bibliographic_titles":[{"bibliographic_title":"The Ocular Surface"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: To evaluate acute corneal permeability changes after instillation of benzalkonium chloride (BAC) using a newly developed in vivo less invasive corneal transepithelial electrical resistance (TER) measurement method in animals and humans. Methods: We previously developed an in vivo method for measuring corneal TER using intraocular electrodes in animals. This method can be used to precisely measure the decline of the corneal barrier function after instillation of BAC. To lessen the invasiveness of that procedure, we further refined the method for measuring the corneal TER by developing electrodes that could be placed on the surface of the cornea and in the conjunctival sac instead of inserting them into the anterior chamber. Corneal TER changes before and after exposure to 0.02% BAC were determined in this study using the new device in both rabbits and humans. Results: There was a significant decrease in the corneal TER after exposure of the cornea to 0.02% BAC solution in both rabbits and humans (P<.01). The results of this new less invasive method agreed with those of formerly established anterior chamber methods in rabbit experiments. Conclusion: This new less invasive corneal TER measurement method enables us for the first time to measure TER of the human cornea, allowing safe and reliable investigation of the direct effect of different eye drop treatments on the corneal epithelium.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"The Ocular Surface, 14(1), pp.37-42; 2016","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier Inc."}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.jtos.2015.07.004","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2016 Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"15420124","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Uematsu, Masafumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mohamed, Yasser Helmy"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Onizuka, Naoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ueki, Ryotaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Inoue, Daisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujikawa, Azusa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sasaki, Hitoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kitaoka, Takashi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"OculSurf14_37.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"OculSurf14_37.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/3751/files/OculSurf14_37.pdf"},"version_id":"f2f6a8ea-115d-4cfc-8c9f-e7eb0dfaf5e5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"benzalkonium chloride","subitem_subject_scheme":"Other"},{"subitem_subject":"cornea","subitem_subject_scheme":"Other"},{"subitem_subject":"transepithelial electrical resistance","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Less Invasive Corneal Transepithelial Electrical Resistance Measurement Method","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Less Invasive Corneal Transepithelial Electrical Resistance Measurement Method"}]},"item_type_id":"2","owner":"2","path":["9"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-02-01"},"publish_date":"2017-02-01","publish_status":"0","recid":"3751","relation_version_is_last":true,"title":["Less Invasive Corneal Transepithelial Electrical Resistance Measurement Method"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:28:57.362895+00:00"}