@article{oai:nagasaki-u.repo.nii.ac.jp:00000394, author = {Toyama, Shiho and Takatani, Ayuko and Koga, Tomohiro and Eguchi, Mizuna and Okamoto, Momoko and Tsuji, Sosuke and Endo, Yushiro and Shimizu, Toshimasa and Sumiyoshi, Remi and Igawa, Takashi and Kawashiri, Shin-ya and Iwamoto, Naoki and Ichinose, Kunihiro and Tamai, Mami and Nakamura, Hideki and Origuchi, Tomoki and Furuyama, Masako and Tabuchi, Maiko and Kobayashi, Shinichiro and Kanetaka, Kengo and Hashisako, Mikiko and Abe, Kuniko and Niino, Daisuke and Sato, Shinya and Miyazaki, Yasushi and Kawakami, Atsushi}, issue = {22}, journal = {Internal Medicine}, month = {Nov}, note = {A 71-year-old woman being treated with methotrexate (MTX) and tacrolimus (TAC) for rheumatoid arthritis (RA) was admitted to our hospital and underwent surgery for gastric perforation and peritonitis. An endoscopic examination six days post-surgery showed an extensive ulcer in the stomach, and a biopsy revealed diffused large B-cell lymphoma. We diagnosed her with immunodeficiency-associated lymphoproliferative disorder (LPD) and discontinued the MTX and TAC. She underwent gastrectomy due to stenosis approximately two months after the first operation, but the histopathological findings of lymphoma had disappeared. LPD should be considered as a potential cause of gastric perforation during RA treatment. c 2019 Japanese Society of Internal Medicine., Internal Medicine, 58(22), pp.3331-3336; 2019}, pages = {3331--3336}, title = {Gastric Perforation due to Iatrogenic Immunodeficiency-associated Lymphoproliferative Disorder during the Treatment of Rheumatoid Arthritis}, volume = {58}, year = {2019} }