@article{oai:nagasaki-u.repo.nii.ac.jp:00000404,
 author = {Luz, Mark Anthony de Vera and Nabeshima, Takeshi and Moi, Meng Ling and Dimamay, Maria Terrese Alonzo and Pangilinan, Lady-Anne Suarez and Dimamay, Mark Pierre Sijo and Matias, Ronald Roll and Mapua, Cynthia Abad and Buerano, Corazon Cerilla and de, Guzman  Ferdinand and Tria, Edith Sangalang and Natividad, Filipinas Florendo and Daroy, Maria Luisa de Guzman and Takemura, Taichiro and Hasebe, Futoshi and Morita, Kouichi},
 issue = {6},
 journal = {Japanese Journal of Infectious Diseases},
 month = {Nov},
 note = {engue remains a major public health problem in the Philippines. In this study, we determined the circulating dengue serotypes in the Philippines during the 2015?2017 outbreaks using a total of 678 serum samples from 537 individual dengue patients. Following an increase in the number of DENV-4 patients in recent years, we conducted a comprehensive molecular and epidemiology analysis on the DENV-4 strains isolated recently in the Philippines. Two genotypes of DENV-4 have been isolated in the Philippines since 1956: GI and GIIa. The GIIa DENV strains that were isolated in the present study were closely related to a distinct group of GIIa strains that were isolated from the Philippines in 2004. A majority of the isolates of this sub-group have been identified in the Philippines, suggesting that this lineage may have been introduced in the Philippines, and evolved to form the distinct sub-group within GIIa strains. The increase in DENV-4 activity also coincided with the appearance of the GIIa sub-group and the phasing-out of the GI lineage in the Philippines. Overall, our study demonstrates a shift in DENV-4 genotype and epidemic dynamics in a hyperendemic region, suggesting the importance of DENV genetic evolution in establishing and sustaining transmission., Japanese Journal of Infectious Diseases, 72(6), pp.413-419; 2019},
 pages = {413--419},
 title = {An Epidemic of Dengue Virus Serotype-4 during the 2015 - 2017: the Emergence of a Novel Genotype IIa of DENV-4 in the Philippines},
 volume = {72},
 year = {2019}
}