@article{oai:nagasaki-u.repo.nii.ac.jp:00004055,
 author = {Miyata, Yasuyoshi and Nomata, Koichiro and Ohba, K. and Matsuo, T. and Hayashi, N. and Sakamoto, I. and Uetani, M. and Sakai, H.},
 issue = {3},
 journal = {European Journal of Surgical Oncology (EJSO)},
 month = {Mar},
 note = {Introduction Patients with muscle-invasive bladder cancer (MIBC) often undergo various preoperative treatments to improve survival; however, their efficacy and safety remain unclear. Materials and methods The anti-tumour effects and adverse events were evaluated in 163 MIBC patients who received systemic chemotherapy (SC, n = 34), intra-arterial chemotherapy (IAC, n = 50), or combined IAC and radiotherapy (IAC + R, n = 79). Results Pathological complete responses were observed in 17.6%, 22.0%, and 43.0% of patients in the SC, IAC, and IAC + R groups, respectively, with respective 5-year overall survival rates of 42.0%, 46.7%, and 50.3%. Multivariate analysis showed that successful IAC + R protocol administration was a significant predictor for survival (hazard ratio = 0.16, p = 0.028). The incidence of severe adverse events was higher in the IAC + R group (36.7%) than in the SC (9.8%) and IAC groups (16.0%). Conclusions IAC + R was useful for patients with MIBC. Successful completion and optimal patient selection were important for this treatment strategy., European Journal of Surgical Oncology (EJSO), 41(3), pp.361-367; 2015},
 pages = {361--367},
 title = {Efficacy and safety of systemic chemotherapy and intra-arterial chemotherapy with/without radiotherapy for bladder preservation or as neo-adjuvant therapy in patients with muscle-invasive bladder cancer: A single-centre study of 163 patients},
 volume = {41},
 year = {2015}
}