{"created":"2023-05-15T16:32:17.970715+00:00","id":4088,"links":{},"metadata":{"_buckets":{"deposit":"f37c0aa2-268e-4dbb-ad54-f7e74673a21c"},"_deposit":{"created_by":6,"id":"4088","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"4088"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00004088","sets":["10:22:24"]},"author_link":["114625","114624"],"item_5_alternative_title_19":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"日本人MuSK抗体陽性重症筋無力症患者の胸腺組織と自己免疫疾患の合併"}]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-06-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"1276","bibliographicPageStart":"1272","bibliographicVolumeNumber":"20","bibliographic_titles":[{"bibliographic_title":"European Journal of Neurology"}]}]},"item_5_date_granted_64":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2013-06-05"}]},"item_5_degree_grantor_62":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"Nagasaki University (長崎大学)"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17301","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_61":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background and purpose: The differences in the characteristics of thymus histology, coexisting autoimmune diseases and related autoantibodies between anti-muscle-specific receptor tyrosine kinase (MuSK)-antibody (Ab)-positive myasthenia gravis (MG) patients, and anti-acetylcholine receptor (AChR)-Ab-positive MG patients are not clearly defined. Methods: The types of thymus histology, coexisting autoimmune diseases and associated Abs in 83 MuSK-Ab-positive patients nationwide were investigated and were compared with those in AChR-Ab-positive patients followed at our institute (n = 83). As for the autoantibodies associated with thymoma, titin Abs were measured. Results: Thymoma was not present in any of the MuSK-Ab-positive patients but presented in 21 patients (25.3%) amongst the AChR-Ab-positive patients. Titin Abs were absent in MuSK-Ab-positive patients but positive in 25 (30.1%) of the AChR-Ab-positive patients. Concomitant autoimmune diseases were present in eight MuSK-Ab-positive patients (9.6%) amongst whom Hashimoto's thyroiditis and rheumatoid arthritis predominated, whereas 22 AChR-Ab-positive patients (26.5%) had one or more concomitant autoimmune diseases of which Graves' disease predominated. Conclusions: Differences in frequency of thymoma and thymic hyperplasia, coexisting autoimmune diseases and autoantibody positivity between MuSK-Ab-positive and AChR-Ab-positive MG were indicated, suggesting that, in contrast with AChR-Ab-positive MG, thymus does not seem to be involved in the pathogenic mechanisms of MuSK-Ab-positive MG.","subitem_description_type":"Abstract"}]},"item_5_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"長崎大学学位論文 学位記番号:博(医歯薬)甲第604号 学位授与年月日:平成25年6月5日","subitem_description_type":"Other"},{"subitem_description":"Author： Nakata Ruka , Motomura Masakatsu , Masuda Tomoko , Shiraishi Hirokazu , Tokuda Masahiro , Fukuda Taku , Ando Takao ,Yoshimura Toshiro , Tsujihata Mitsuhiro , Kawakami Atsushi","subitem_description_type":"Other"},{"subitem_description":"Citation: European Journal of Neurology, 20(9), pp.1272-1276; 2013","subitem_description_type":"Other"}]},"item_5_description_69":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Nagasaki University (長崎大学), 博士(医学) (2013-06-05)","subitem_description_type":"Other"}]},"item_5_dissertation_number_65":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲医歯薬第604号"}]},"item_5_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"114625","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Nakata, Ruka"}]}]},"item_5_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Blackwell Publishing"}]},"item_5_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/ene.12169","subitem_relation_type_select":"DOI"}}]},"item_5_relation_42":{"attribute_name":"関係URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://hdl.handle.net/10069/34114","subitem_relation_type_select":"HDL"}}]},"item_5_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2013 EFNS."},{"subitem_rights":"This is the accepted version of the following article: European Journal of Neurology, 20(9), pp.1272-1276; 2013, which has been published in final form at http://dx.doi.org/10.1111/ene.12169"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13515101","subitem_source_identifier_type":"ISSN"}]},"item_5_text_67":{"attribute_name":"学位の種類","attribute_value_mlt":[{"subitem_text_value":"課程博士"}]},"item_5_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中田, るか"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-02-01"}],"displaytype":"detail","filename":"ISYK604_Nakata.pdf","filesize":[{"value":"173.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ISYK604_Nakata.pdf","objectType":"fulltext","url":"https://nagasaki-u.repo.nii.ac.jp/record/4088/files/ISYK604_Nakata.pdf"},"version_id":"f2f1547d-2c92-4872-a8c8-eefb47369a9a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Associated autoimmune disease","subitem_subject_scheme":"Other"},{"subitem_subject":"Muscle-specific receptor tyrosine kinase","subitem_subject_scheme":"Other"},{"subitem_subject":"Myasthenia gravis","subitem_subject_scheme":"Other"},{"subitem_subject":"Thymus","subitem_subject_scheme":"Other"},{"subitem_subject":"Titin antibodies","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Thymus histology and concomitant autoimmune diseases in Japanese patients with MuSK-　antibody-　positive myasthenia gravis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Thymus histology and concomitant autoimmune diseases in Japanese patients with MuSK-　antibody-　positive myasthenia gravis","subitem_title_language":"en"}]},"item_type_id":"5","owner":"6","path":["24"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2015-04-08"},"publish_date":"2015-04-08","publish_status":"0","recid":"4088","relation_version_is_last":true,"title":["Thymus histology and concomitant autoimmune diseases in Japanese patients with MuSK-　antibody-　positive myasthenia gravis"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-08-23T05:02:53.613573+00:00"}