{"created":"2023-05-15T16:32:20.420020+00:00","id":4146,"links":{},"metadata":{"_buckets":{"deposit":"1e1b4e0a-8098-489f-8a8c-90cb97be9e1a"},"_deposit":{"created_by":2,"id":"4146","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"4146"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00004146","sets":["29:30"]},"author_link":["16503","16509","16511","16512","16515","16507","16505","16514","16516","16510","16504","16517","16506","16513","16508"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"120","bibliographicPageStart":"114","bibliographicVolumeNumber":"157","bibliographic_titles":[{"bibliographic_title":"Clinical Immunology"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Neuropsychiatric systemic lupus erythematosus (NPSLE) is a serious complication in SLE. Although the mechanism of NPSLE remains unclear, cytokines and chemokines are considered to be involved in their pathogenesis. Here we used Bio-Plex Pro assays to examine 27 types of cytokines and chemokines in the cerebrospinal fluid (CSF) of 32 NPSLE patients. We used the CSF of 20 patients with multiple sclerosis (MS) and 22 patients with neuromyelitis optica (NMO) as a disease control group. Fourteen of 27 cytokines/chemokines were significantly higher in the NPSLE patients compared to the MS/NMO patients. We could identify six \"minimum predictive markers\" by using a weighted-voting algorithm that could distinguish NPSLE from MS and NMO: interleukin (IL)-17, IL-2, interferon (IFN)-γ, IL-5, basic fibroblast growth factor (FGF)-basic and IL-15. The determination of various types of CSF cytokine profiles may contribute to the diagnosis of NPSLE and may help elucidate the mechanisms underlying this disease.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Clinical Immunology, 157(2), pp.114-120; 2015","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Academic Press Inc."}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.clim.2015.01.010","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2015 Elsevier Inc."},{"subitem_rights":"NOTICE: this is the author’s version of a work that was accepted for publication in  Clinical Immunology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in  Clinical Immunology, 157, 2, (2015)"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"15216616","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ichinose, Kunihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Arima, Kazuhiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ushigusa, Takeshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishino, Ayako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakashima, Yoshikazu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Takahisa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Horai, Yoshiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakajima, Hideki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawashiri, Shin-ya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iwamoto, Naoki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tamai, Mami"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamura, Hideki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Origuchi, Tomoki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Motomura, Masakatsu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawakami, Atsushi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"CliImm157_114.pdf","filesize":[{"value":"517.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"CliImm157_114.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/4146/files/CliImm157_114.pdf"},"version_id":"50d08a04-26cf-4e17-9906-6a7153e364c5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Cerebrospinal fluid","subitem_subject_scheme":"Other"},{"subitem_subject":"Cytokine profiles","subitem_subject_scheme":"Other"},{"subitem_subject":"Neuropsychiatric systemic lupus erythematosus","subitem_subject_scheme":"Other"},{"subitem_subject":"Weighted-voting algorithm","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Distinguishing the cerebrospinal fluid cytokine profile in neuropsychiatric systemic lupus erythematosus from other autoimmune neurological diseases","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Distinguishing the cerebrospinal fluid cytokine profile in neuropsychiatric systemic lupus erythematosus from other autoimmune neurological diseases"}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-04-30"},"publish_date":"2015-04-30","publish_status":"0","recid":"4146","relation_version_is_last":true,"title":["Distinguishing the cerebrospinal fluid cytokine profile in neuropsychiatric systemic lupus erythematosus from other autoimmune neurological diseases"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:25:37.392805+00:00"}