{"created":"2023-05-15T16:32:20.985380+00:00","id":4159,"links":{},"metadata":{"_buckets":{"deposit":"dd604422-384f-4b94-acf7-6f0571721494"},"_deposit":{"created_by":2,"id":"4159","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"4159"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00004159","sets":["73:74"]},"author_link":["16621","16623","16624","16620","16619","16622"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-03-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"224","bibliographicPageStart":"218","bibliographicVolumeNumber":"63","bibliographic_titles":[{"bibliographic_title":"Chemical and Pharmaceutical Bulletin"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The influence of D -Leu residues on the helical structures of L -Leu-based-nonapeptides was investigated. Specifically, the preferred conformations of four diastereomeric nonapeptides, Boc-(L -Leu- L -Leu-Aib) 3 - OMe (1); Boc-(L -Leu- L -Leu-Aib)2 - L -Leu- D -Leu-Aib-OMe (2), which contained one D -Leu residue; Boc- L -Leu-D -Leu-Aib- L -Leu- L -Leu-Aib- L -Leu- D -Leu-Aib-OMe (3), which contained two D -Leu residues; and Boc-(L -Leu- D -Leu-Aib)3 - OMe (4), were analyzed in solution and in the crystalline state. Peptide 1 formed a righthanded (P) 310 -helix in solution. Peptides 2 and 3 both formed (P ) 310- helices in solution and (P ) α - helices in the crystalline state. Peptide 4 formed a (P ) α -helix both in solution and in the crystalline state. c 2015 The Pharmaceutical Society of Japan α -aminoisobutyric acid; peptide; conformation; helical structure.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Chemical and Pharmaceutical Bulletin, 63(3), pp.218-224; 2015","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本薬学会"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1248/cpb.c14-00760","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2015 The Pharmaceutical Society of Japan"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00092363","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"13475223","subitem_source_identifier_type":"ISSN"}]},"item_2_text_62":{"attribute_name":"出版者別言語","attribute_value_mlt":[{"subitem_text_value":"Pharmaceutical Society of Japan"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Demizu, Yosuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamashita, Hiroko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Misawa, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Doi, Mitsunobu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanaka, Masakazu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kurihara, Masaaki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"CPBul63_218.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"CPBul63_218.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/4159/files/CPBul63_218.pdf"},"version_id":"0b41cd58-cbe7-46d3-b44f-08e440384bed"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effects of D-Leu Residues on the Helical Secondary Structures of L-Leu-Based Nonapeptides","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of D-Leu Residues on the Helical Secondary Structures of L-Leu-Based Nonapeptides"}]},"item_type_id":"2","owner":"2","path":["74"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-05-08"},"publish_date":"2015-05-08","publish_status":"0","recid":"4159","relation_version_is_last":true,"title":["Effects of D-Leu Residues on the Helical Secondary Structures of L-Leu-Based Nonapeptides"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:25:17.706349+00:00"}