{"created":"2023-05-15T16:32:21.156933+00:00","id":4163,"links":{},"metadata":{"_buckets":{"deposit":"a5d59fc0-b81e-4610-a9ab-5e89bda4ee23"},"_deposit":{"created_by":2,"id":"4163","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"4163"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00004163","sets":["35:36"]},"author_link":["16649","16648","16647","16650","16651","16653","16652"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-01-28","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"23","bibliographicVolumeNumber":"14","bibliographic_titles":[{"bibliographic_title":"Malaria Journal"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Immunity to malaria requires innate, adaptive immune responses and Plasmodium-specific memory cells. Previously, mice semi-immune to malaria was developed. Three cycles of infection and cure ('three-cure') were required to protect mice against Plasmodium berghei (ANKA strain) infection. Methods: C57BL/6 J mice underwent three cycles of P. berghei infection and drug-cure to become semi-immune. The spleens of infected semi-immune mice were collected for flow cytometry analysis. CD11c(+) cells of semiimmune mice were isolated and transferred into naive mice which were subsequently challenged and followed up by survival and parasitaemia. Results: The percentages of splenic CD4(+) and CD11c(+) cells were increased in semi-immune mice on day 7 post-infection. The proportion and number of B220(+)CD11c(+)low cells (plasmacytoid dendritic cells, DCs) was higher in semi-immune, three-cure mice than in their naive littermates on day 7 post-infection (2.6 vs 1.1% and 491,031 vs 149,699, respectively). In adoptive transfer experiment, three months after the third cured P. berghei infection, splenic CD11c(+) DCs of non-infected, semi-immune, three-cure mice slowed Plasmodium proliferation and decreased the death rate due to neurological pathology in recipient mice. In addition, anti-P. berghei IgG1 level was higher in mice transferred with CD11c(+) cells of semi-immune, three-cure mice than mice transferred with CD11c(+) cells of naive counterparts. Conclusion: CD11c(+) cells of semi-immune mice protect against experimental cerebral malaria three months after the third cured malaria, potentially through protective plasmacytoid DCs and enhanced production of malaria-specific antibody.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Malaria Journal, 14, 23; 2015","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"BioMed Central"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1186/s12936-014-0533-y","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2015 Bao et al.; licensee Biomed Central."},{"subitem_rights":"This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated."}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"14752875","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Bao, Lam Quoc"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nhi, Dang M."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Huy, Nguyen Tien"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kikuchi, Mihoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yanagi, Tetsuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hamano, Shinjiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hirayama, Kenji"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"MalJou14_23.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"MalJou14_23.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/4163/files/MalJou14_23.pdf"},"version_id":"1d94e8b8-6633-4244-ad08-c1c9df9bfb74"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"CD11c(+) DCs","subitem_subject_scheme":"Other"},{"subitem_subject":"Cerebral malaria","subitem_subject_scheme":"Other"},{"subitem_subject":"Malaria-specific antibody","subitem_subject_scheme":"Other"},{"subitem_subject":"Plasmacytoid DCs","subitem_subject_scheme":"Other"},{"subitem_subject":"Semi-immune","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Splenic CD11c(+) cells derived from semi-immune mice protect naive mice against experimental cerebral malaria","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Splenic CD11c(+) cells derived from semi-immune mice protect naive mice against experimental cerebral malaria"}]},"item_type_id":"2","owner":"2","path":["36"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-05-08"},"publish_date":"2015-05-08","publish_status":"0","recid":"4163","relation_version_is_last":true,"title":["Splenic CD11c(+) cells derived from semi-immune mice protect naive mice against experimental cerebral malaria"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:25:11.322273+00:00"}