{"created":"2023-05-15T16:32:25.424032+00:00","id":4262,"links":{},"metadata":{"_buckets":{"deposit":"1ad5f24c-27d6-4abc-8636-462c218ffa68"},"_deposit":{"created_by":2,"id":"4262","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"4262"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00004262","sets":["25:26"]},"author_link":["17109","17127","17129","17128","17120","17111","17113","17124","17112","17116","17118","17125","17110","17130","17131","17119","17122","17121","17117","17115","17123","17126","17114"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-10-17","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageStart":"e252","bibliographicVolumeNumber":"4","bibliographic_titles":[{"bibliographic_title":"Blood Cancer Journal"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The superiority of the pediatric protocol for adolescents with acute lymphoblastic leukemia (ALL) has already been demonstrated, however, its efficacy in young adults remains unclear. The ALL202-U protocol was conducted to examine the efficacy and feasibility of a pediatric protocol in adolescents and young adults (AYAs) with BCR'ABL-negative ALL. Patients aged 15'24 years (n = 139) were treated with the same protocol used for pediatric B-ALL. The primary objective of this study was to assess the disease-free survival (DFS) rate and its secondary aims were to assess toxicity, the complete remission (CR) rate and the overall survival (OS) rate. The CR rate was 94%. The 5-year DFS and OS rates were 67% (95% confidence interval (CI) 58'75%) and 73% (95% CI 64'80%), respectively. Severe adverse events were observed at a frequency that was similar to or lower than that in children treated with the same protocol. Only insufficient maintenance therapy significantly worsened the DFS (hazard ratio 5.60, Po0.001).These results indicate that this protocol may be a feasible and highly effective treatment for AYA with BCR'ABL-negative ALL.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Blood Cancer Journal, 4(10), e252; 2014","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nature Publishing Group"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/bcj.2014.72","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2014 Macmillan Publishers Limited"},{"subitem_rights":"This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/."}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"20445385","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hayakawa, Fumihiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakura, T"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yujiri, Toshiaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kondo, Eisei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujimaki, K"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sasaki, O"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyatake, Junichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Handa, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ueda, Yasunori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Aoyama, Y"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takada, Satoru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanaka, Y"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Usui, N"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyawaki, S"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suenobu, Soichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Horibe, Keizo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kiyoi, Hitoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohnishi, Kazunori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyazaki, Yasushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohtake, S"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kobayashi, Yukio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuo, Keitaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Naoe, Tomoki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"BCJ4_e252.pdf","filesize":[{"value":"536.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"BCJ4_e252.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/4262/files/BCJ4_e252.pdf"},"version_id":"342fb80a-7e7f-4ccd-b211-5cd5aa980aae"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Markedly improved outcomes and acceptable toxicity in adolescents and young adults with acute lymphoblastic leukemia following treatment with a pediatric protocol: a phase II study by the Japan Adult Leukemia Study Group","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Markedly improved outcomes and acceptable toxicity in adolescents and young adults with acute lymphoblastic leukemia following treatment with a pediatric protocol: a phase II study by the Japan Adult Leukemia Study Group"}]},"item_type_id":"2","owner":"2","path":["26"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-05-25"},"publish_date":"2015-05-25","publish_status":"0","recid":"4262","relation_version_is_last":true,"title":["Markedly improved outcomes and acceptable toxicity in adolescents and young adults with acute lymphoblastic leukemia following treatment with a pediatric protocol: a phase II study by the Japan Adult Leukemia Study Group"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:23:29.327845+00:00"}