{"created":"2023-05-15T16:32:25.943248+00:00","id":4274,"links":{},"metadata":{"_buckets":{"deposit":"3f7af0af-13e0-4a2c-9e42-9cde67f6702a"},"_deposit":{"created_by":6,"id":"4274","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"4274"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00004274","sets":["10:22:24"]},"author_link":["114752","114751"],"item_5_alternative_title_19":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"リーシュマニア原虫感染において、樹状細胞に発現されるIRF4はIL-12産生を抑制しTh1免疫応答を制御する。"}]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-03-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"2279","bibliographicPageStart":"2271","bibliographicVolumeNumber":"192","bibliographic_titles":[{"bibliographic_title":"The Journal of Immunology"}]}]},"item_5_date_granted_64":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2014-03-20"}]},"item_5_degree_grantor_62":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"Nagasaki University (長崎大学)"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17301","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_61":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"IRF4 is a transcription factor from the IRF factor family that plays pivotal roles in the differentiation and function of T and B lymphocytes. Although IRF4 is also expressed in dendritic cells (DCs) and macrophages, its roles in these cells in vivo are not clearly understood. In this study, conditional knockout mice that lack IRF4 in DCs or macrophages were generated and infected with Leishmania major. Mice lacking DC expression of IRF4 showed reduced footpad swelling compared with C57BL/6 mice, whereas those lacking IRF4 in macrophages did not. Mice with IRF4-deficient DCs also showed reduced parasite burden, and their CD4+ T cells produced higher levels of IFN-g in response to L. major Ag. In the draining lymph nodes, the proportion of activated CD4+ T cells in these mice was similar to that in the control, but the proportion of IFN-g-producing cells was increased, suggesting a Th1 bias in the immune response. Moreover, the numbers of migrating Langerhans cells and other migratory DCs in the draining lymph nodes were reduced both before and postinfection in mice with IRF4 defects in DCs, but higher levels of IL-12 were observed in IRF4-deficient DCs. These results imply that IRF4 expression in DCs inhibits their ability to produce IL-12 while promoting their migratory behavior, thus regulating CD4+ T cell responses against local infection with L. major.","subitem_description_type":"Abstract"}]},"item_5_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"長崎大学学位論文 学位記番号:博(医歯薬)甲第653号 学位授与年月日:平成26年3月20日","subitem_description_type":"Other"},{"subitem_description":"Author: Masoud Akbari, Kiri Honma, Daisuke Kimura, Mana Miyakoda, Kazumi Kimura, Toshifumi Matsuyama and Katsuyuki Yui","subitem_description_type":"Other"},{"subitem_description":"Citation: Journal of Immunology, 192(5), pp.2271-2279; 2014","subitem_description_type":"Other"}]},"item_5_description_69":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Nagasaki University (長崎大学), 博士(医学) (2014-03-20)","subitem_description_type":"Other"}]},"item_5_dissertation_number_65":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲医歯薬第653号"}]},"item_5_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"114752","nameIdentifierScheme":"WEKO"}],"names":[{"name":"アキバリ, マスード"}]}]},"item_5_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The American Association of Immunologists, Inc."}]},"item_5_relation_42":{"attribute_name":"関係URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://hdl.handle.net/10069/34586","subitem_relation_type_select":"HDL"}}]},"item_5_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(C) 2014 by The American Association of Immunologists, Inc."},{"subitem_rights":"The American Association of Immunologists, Inc., grant Dr. Akbari permission to reproduce the article in his thesis."}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00221767","subitem_source_identifier_type":"ISSN"}]},"item_5_text_67":{"attribute_name":"学位の種類","attribute_value_mlt":[{"subitem_text_value":"課程博士"}]},"item_5_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Akbari, Masoud"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-02-01"}],"displaytype":"detail","filename":"ISYK653_Akbari.pdf","filesize":[{"value":"728.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ISYK653_Akbari.pdf","objectType":"fulltext","url":"https://nagasaki-u.repo.nii.ac.jp/record/4274/files/ISYK653_Akbari.pdf"},"version_id":"362a932a-e937-44ea-ab07-1f2d83c9cfc6"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"IFN regulatory factor 4 (IRF4) in dendritic cells inhibits IL-12 production and controls Th1 immune responses against Leishmania major","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"IFN regulatory factor 4 (IRF4) in dendritic cells inhibits IL-12 production and controls Th1 immune responses against Leishmania major","subitem_title_language":"en"}]},"item_type_id":"5","owner":"6","path":["24"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2015-05-27"},"publish_date":"2015-05-27","publish_status":"0","recid":"4274","relation_version_is_last":true,"title":["IFN regulatory factor 4 (IRF4) in dendritic cells inhibits IL-12 production and controls Th1 immune responses against Leishmania major"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-08-23T05:02:58.625205+00:00"}