@article{oai:nagasaki-u.repo.nii.ac.jp:00000439,
 author = {Musa, Md. Abu and Nakamura, Risa and Hena, Asma and Varikuti, Sanjay and Nakhasi, Hira L. and Goto, Yasuyuki and Satoskar, Abhay R. and Hamano, Shinjiro},
 issue = {11},
 journal = {PLOS Neglected Tropical Diseases},
 month = {Nov},
 note = {Cutaneous leishmaniasis (CL) is the most common form of leishmaniasis and is caused by
several species of Leishmania parasite. Clinical presentation of CL varies from a self-healing
infection to a chronic form of the disease determined by the virulence of infecting Leishmania
species and host immune responses to the parasite. Mouse models of CL show
contradictory roles of lymphocytes in pathogenesis, while acquired immune responses are
responsible for host protection from diseases. To reconcile the inconclusive roles of
acquired immune responses in pathogenesis, we infected mice from various genetic backgrounds
with two pathogenic strains of Leishmania major, Friedlin or 5ASKH, and assessed
the outcome of the infections. Our findings showed that the genetic backgrounds of L. major
determine the impact of lymphocytes for pathogenesis. In the absence of lymphocytes, L.
major Friedlin induced the lowest inflammatory reaction and pathology at the site of infection,
while 5ASKH infection induced a strong inflammatory reaction and severe pathology.
Lymphocytes ameliorated 5ASKH mediated pathology, while it exacerbated pathology during
Friedlin infection. Excess inflammatory reactions, like the recruitment of macrophages,
neutrophils, eosinophils and production of pro-inflammatory cytokines, together with uncontrolled
parasite growth in the absence of lymphocytes during 5ASKH infection may induce
severe pathology development. Taken together our study provides insight into the impact of
differences in the genetic background of Leishmania on CL pathogenesis., PLoS neglected tropical diseases, 13(11), e0007865; 2019},
 title = {Lymphocytes influence Leishmania major pathogenesis in a strain-dependent manner},
 volume = {13},
 year = {2019}
}