{"created":"2023-05-15T16:29:37.276254+00:00","id":439,"links":{},"metadata":{"_buckets":{"deposit":"5e889821-98d1-46f4-88f8-86ea9a2a91fe"},"_deposit":{"created_by":2,"id":"439","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"439"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00000439","sets":["35:36"]},"author_link":["2237","2241","2238","2239","2240","2242","2243","2244"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-11-18","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageStart":"e0007865","bibliographicVolumeNumber":"13","bibliographic_titles":[{"bibliographic_title":"PLOS Neglected Tropical Diseases"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Cutaneous leishmaniasis (CL) is the most common form of leishmaniasis and is caused by\nseveral species of Leishmania parasite. Clinical presentation of CL varies from a self-healing\ninfection to a chronic form of the disease determined by the virulence of infecting Leishmania\nspecies and host immune responses to the parasite. Mouse models of CL show\ncontradictory roles of lymphocytes in pathogenesis, while acquired immune responses are\nresponsible for host protection from diseases. To reconcile the inconclusive roles of\nacquired immune responses in pathogenesis, we infected mice from various genetic backgrounds\nwith two pathogenic strains of Leishmania major, Friedlin or 5ASKH, and assessed\nthe outcome of the infections. Our findings showed that the genetic backgrounds of L. major\ndetermine the impact of lymphocytes for pathogenesis. In the absence of lymphocytes, L.\nmajor Friedlin induced the lowest inflammatory reaction and pathology at the site of infection,\nwhile 5ASKH infection induced a strong inflammatory reaction and severe pathology.\nLymphocytes ameliorated 5ASKH mediated pathology, while it exacerbated pathology during\nFriedlin infection. Excess inflammatory reactions, like the recruitment of macrophages,\nneutrophils, eosinophils and production of pro-inflammatory cytokines, together with uncontrolled\nparasite growth in the absence of lymphocytes during 5ASKH infection may induce\nsevere pathology development. Taken together our study provides insight into the impact of\ndifferences in the genetic background of Leishmania on CL pathogenesis.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"PLoS neglected tropical diseases, 13(11), e0007865; 2019","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Public Library of Science"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1371/journal.pntd.0007865","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This is an open access article, free of allcopyright, and may be freely reproduced,distributed, transmitted, modified, built upon, orotherwise used by anyone for any lawful purposeThe work is made available under the Creative Commons CC0 public domain dedication.."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"19352727","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"19352735","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Musa, Md. Abu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamura, Risa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hena, Asma"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Varikuti, Sanjay"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakhasi, Hira L."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Goto, Yasuyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Satoskar, Abhay R."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hamano, Shinjiro"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-18"}],"displaytype":"detail","filename":"PLoSNeg13_7865.pdf","filesize":[{"value":"1.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PLoSNeg13_7865.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/439/files/PLoSNeg13_7865.pdf"},"version_id":"4a41cf22-66c0-4f8a-8f80-0490979fa3bb"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Lymphocytes influence Leishmania major pathogenesis in a strain-dependent manner","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Lymphocytes influence Leishmania major pathogenesis in a strain-dependent manner"}]},"item_type_id":"2","owner":"2","path":["36"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-12-19"},"publish_date":"2019-12-19","publish_status":"0","recid":"439","relation_version_is_last":true,"title":["Lymphocytes influence Leishmania major pathogenesis in a strain-dependent manner"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:16:51.529996+00:00"}