{"created":"2023-05-15T16:29:37.574537+00:00","id":446,"links":{},"metadata":{"_buckets":{"deposit":"d0e1bca3-433f-4ba2-acfe-414dbc79744c"},"_deposit":{"created_by":2,"id":"446","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"446"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00000446","sets":["10:11"]},"author_link":["2287","2289","2284","2282","2280","2285","2283","2286","2288","2281","2278","2279"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-12-16","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"24","bibliographicPageStart":"4601","bibliographicVolumeNumber":"24","bibliographic_titles":[{"bibliographic_title":"Molecules"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Human prion diseases are neurodegenerative disorders caused by prion protein. Although infectivity was historically detected only in the central nervous system and lymphoreticular tissues of patients with sporadic Creutzfeldt-Jakob disease, recent reports suggest that the seeding activity of Creutzfeldt-Jakob disease prions accumulates in various non-neuronal organs including the liver, kidney, and skin. Therefore, we reanalyzed autopsy samples collected from patients with sporadic and genetic human prion diseases and found that seeding activity exists in almost all digestive organs. Unexpectedly, activity in the esophagus reached a level of prion seeding activity close to that in the central nervous system in some CJD patients, indicating that the safety of endoscopic examinations should be reconsidered.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Molecules, 24(24), art.no.4601; 2019","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3390/molecules24244601","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)."}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1420-3049","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Satoh, Katsuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fuse, Takayuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nonaka, Toshiaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Dong, Trong"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takao, Masaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakagaki, Takehiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishibashi, Daisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Taguchi, Yuzuru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mihara, Ban"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iwasaki, Yasushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshida, Mari"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishida, Noriyuki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-18"}],"displaytype":"detail","filename":"molecules24_4601.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"molecules24_4601.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/446/files/molecules24_4601.pdf"},"version_id":"313d4d17-a2d6-4293-aefe-8c4aa5309453"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"prion","subitem_subject_scheme":"Other"},{"subitem_subject":"rt-quic","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Postmortem Quantitative Analysis of Prion Seeding Activity in the Digestive System","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Postmortem Quantitative Analysis of Prion Seeding Activity in the Digestive System"}]},"item_type_id":"2","owner":"2","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-01-10"},"publish_date":"2020-01-10","publish_status":"0","recid":"446","relation_version_is_last":true,"title":["Postmortem Quantitative Analysis of Prion Seeding Activity in the Digestive System"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:16:46.981414+00:00"}