{"created":"2023-05-15T16:32:35.113036+00:00","id":4486,"links":{},"metadata":{"_buckets":{"deposit":"fec85405-fd25-471d-bf7b-0a1a8db47ac9"},"_deposit":{"created_by":2,"id":"4486","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"4486"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00004486","sets":["10:11"]},"author_link":["17891","17886","17896","17897","17887","17895","17888","17890","17893","17892","17889","17894"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-05-22","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageStart":"e0127460","bibliographicVolumeNumber":"10","bibliographic_titles":[{"bibliographic_title":"PLOS ONE"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Mucosa-associated lymphoid tissue (MALT) is a group of secondary and organized lymphoid tissue that develops at different mucosal surfaces. Peyer's patches (PPs), nasopharynx-associated lymphoid tissue (NALT), and tear duct-associated lymphoid tissue (TALT) are representative MALT in the small intestine, nasal cavity, and lacrimal sac, respectively. A recent study has shown that transcriptional regulators of core binding factor (Cbf) β2 and promotor-1-transcribed Runt-related transcription factor 1 (P1-Runx1) are required for the differentiation of CD3-CD4+CD45+ lymphoid tissue inducer (LTi) cells, which initiate and trigger the developmental program of PPs, but the involvement of this pathway in NALT and TALT development remains to be elucidated. Here we report that Cbfβ2 plays an essential role in NALT and TALT development by regulating LTi cell trafficking to the NALT and TALT anlagens. Cbfβ2 was expressed in LTi cells in all three types of MALT examined. Indeed, similar to the previous finding for PPs, we found that Cbfβ2-/- mice lacked NALT and TALT lymphoid structures. However, in contrast to PPs, NALT and TALT developed normally in the absence of P1-Runx1 or other Runx family members such as Runx2 and Runx3. LTi cells for NALT and TALT differentiated normally but did not accumulate in the respective lymphoid tissue anlagens in Cbfβ2-/- mice. These findings demonstrate that Cbfβ2 is a central regulator of the MALT developmental program, but the dependency of Runx proteins on the lymphoid tissue development would differ among PPs, NALT, and TALT.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"PLOS ONE, 10(5), e0127460; 2015","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Public Library of Science"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1371/journal.pone.0127460","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2015 Nagatake et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"19326203","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nagatake, Takahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukuyama, Satoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Shintaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okura, Hideaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tachibana, Masashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Taniuchi, Ichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ito, Kosei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimojou, Michiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsumoto, Naomi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Hidehiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kunisawa, Jun"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kiyono, Hiroshi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"PLoS10_127460.pdf","filesize":[{"value":"12.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PLoS10_127460.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/4486/files/PLoS10_127460.pdf"},"version_id":"937a8b07-d4b2-4a54-bfab-3707979ae9bb"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Central Role of Core Binding Factor β2 in Mucosa-Associated Lymphoid Tissue Organogenesis in Mouse","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Central Role of Core Binding Factor β2 in Mucosa-Associated Lymphoid Tissue Organogenesis in Mouse"}]},"item_type_id":"2","owner":"2","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-07-09"},"publish_date":"2015-07-09","publish_status":"0","recid":"4486","relation_version_is_last":true,"title":["Central Role of Core Binding Factor β2 in Mucosa-Associated Lymphoid Tissue Organogenesis in Mouse"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:20:58.992971+00:00"}