{"created":"2023-05-15T16:32:39.450023+00:00","id":4587,"links":{},"metadata":{"_buckets":{"deposit":"5c74f2c0-3c6c-44cc-8180-9ac389ed82f3"},"_deposit":{"created_by":2,"id":"4587","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"4587"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00004587","sets":["29:30"]},"author_link":["18230","18232","18231","18224","18229","18226","18223","18225","18222","18228","18227"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-07-09","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"7679","bibliographicVolumeNumber":"6","bibliographic_titles":[{"bibliographic_title":"Nature Communications"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Crosstalk between inflammatory signalling pathways and receptor tyrosine kinases has been revealed as an indicator of cancer malignant progression. In the present study, we focus on EphA2 receptor tyrosine kinase, which is overexpressed in many human cancers. It has been reported that ligand-independent phosphorylation of EphA2 at Ser-897 is induced by Akt. We show that inflammatory cytokines promote RSK-, not Akt-, dependent phosphorylation of EphA2 at Ser-897. In addition, the RSK-EphA2 signalling pathway controls cell migration and invasion of metastatic breast cancer cells. Moreover, Ser-897-phosphorylated EphA2 co-localizes with phosphorylated active form of RSK in various human tumour specimens, and this double positivity is related to poor survival in lung cancer patients, especially those with a smoking history. Taken together, these results indicate that the phosphorylation of EphA2 at Ser-897 is controlled by RSK and the RSK-EphA2 axis might contribute to cell motility and promote tumour malignant progression.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Nature Communications, 6, 7679; 2015","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nature Publishing Group"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/ncomms8679","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2015 Macmillan Publishers Limited."},{"subitem_rights":"This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"20411723","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Zhou, Yue"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamada, Naoki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanaka, Tomohiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hori, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yokoyama, Satoru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hayakawa, Yoshihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yano, Seiji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukuoka, Junya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Koizumi, Keiichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Saiki, Ikuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakurai, Hiroaki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"NaCom6_7679.pdf","filesize":[{"value":"2.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"NaCom6_7679.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/4587/files/NaCom6_7679.pdf"},"version_id":"8baebd14-c00c-4887-891d-85250f6fd6cb"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2"}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-08-03"},"publish_date":"2015-08-03","publish_status":"0","recid":"4587","relation_version_is_last":true,"title":["Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:19:23.297782+00:00"}