{"created":"2023-05-15T16:32:40.573618+00:00","id":4613,"links":{},"metadata":{"_buckets":{"deposit":"93d33548-08f2-4d1f-9f9d-a2bf5a7fd992"},"_deposit":{"created_by":2,"id":"4613","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"4613"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00004613","sets":["29:30:1713167819629:297"]},"author_link":["18462","18461","18460","18456","18457","18459","18458"],"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"19","bibliographicPageStart":"13","bibliographicVolumeNumber":"60","bibliographic_titles":[{"bibliographic_title":"Acta medica Nagasakiensia"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: The similarities between Kawasaki disease (KD) and superantigen (SA) diseases indicate that a microbial SA might cause KD. Viral diseases can trigger an endogenous SA.\nMethods: We evaluated expression of Vβ2 (responding to staphylococcal TSST-1) and Vβ7 (responding to the endogenous SA induced by type-1 interferon or Epstein-Barr virus infection) on T cells from 70 KD patients along with the following control subjects: 18 non-vasculitic patients (NVs), 7 patients with anaphylactoid purpura (AP), and two with neonatal TSS-like exanthematous disease (NTED), a typical SA disease. We examined the correlation of clinical features of KD with Vβ2+ or Vβ7+CD4+T cell populations.\nResults: The Vβ2+CD4+T cell rates were comparable between KD patients (9.9±2.9%) and NVs (9.0±1.8%), but were lower in AP patients (6.6±1.8%). However, the Vβ2+CD4+T cell rate was significantly higher in KD patients with erythematic BCG inoculation site lesions (10.8±3.2%) than in those without (8.8±2.1%) and NVs (9.0±1.8%), but much lower than in NTED patients (25.2%, 16.9%). Multivariate linear regression analysis with elevation of Vβ2 expression as a dependent variable revealed significant correlations with BCG. In contrast, Vβ7+CD4+T cell rates were not significantly different between KD patients and other study subjects.\nConclusion: While we were unable to find evidence supporting the involvement of the endogenous SA in the pathogenesis of KD in this study, modest expansion of the Vβ2+CD4+T cell population in a subgroup of KD with erythematic BCG inoculation site lesions implies the involvement of a microbial agent(s) different from TSST-1 as well as immunopathological heterogeneity of KD. (249 words)","subitem_description_type":"Abstract"}]},"item_3_description_64":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Acta medica Nagasakiensia, 60(1), pp.13-19; 2015","subitem_description_type":"Other"}]},"item_3_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nagasaki University School of Medicine"}]},"item_3_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508430","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00016055","subitem_source_identifier_type":"ISSN"}]},"item_3_text_62":{"attribute_name":"sortkey","attribute_value_mlt":[{"subitem_text_value":"3"}]},"item_3_text_63":{"attribute_name":"出版者別言語","attribute_value_mlt":[{"subitem_text_value":"長崎大学医学部"}]},"item_3_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Motomura, Hideki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hasuwa, Tomoyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ushiroda, Yohko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakagaki, Mari"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Honda, Sumihisa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Moriuchi, Masako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Moriuchi, Hiroyuki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"ActMed60_13.pdf","filesize":[{"value":"630.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ActMed60_13.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/4613/files/ActMed60_13.pdf"},"version_id":"bb201bbf-991c-4fb6-bd16-65e8f9860984"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Kawasaki disease","subitem_subject_scheme":"Other"},{"subitem_subject":"superantigen","subitem_subject_scheme":"Other"},{"subitem_subject":"Vβ2","subitem_subject_scheme":"Other"},{"subitem_subject":"Vβ7","subitem_subject_scheme":"Other"},{"subitem_subject":"toxic shock syndrome toxin-1","subitem_subject_scheme":"Other"},{"subitem_subject":"BCG","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Modest Expansion of Vβ2+CD4+ T Cells and No Expansion of Vβ7+CD4+ T Cells in a Subgroup of Kawasaki Disease Patients with Erythematic BCG Inoculation Site Lesions","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Modest Expansion of Vβ2+CD4+ T Cells and No Expansion of Vβ7+CD4+ T Cells in a Subgroup of Kawasaki Disease Patients with Erythematic BCG Inoculation Site Lesions"}]},"item_type_id":"3","owner":"2","path":["297"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-08-07"},"publish_date":"2015-08-07","publish_status":"0","recid":"4613","relation_version_is_last":true,"title":["Modest Expansion of Vβ2+CD4+ T Cells and No Expansion of Vβ7+CD4+ T Cells in a Subgroup of Kawasaki Disease Patients with Erythematic BCG Inoculation Site Lesions"],"weko_creator_id":"2","weko_shared_id":2},"updated":"2024-04-16T05:28:13.607143+00:00"}