{"created":"2023-05-15T16:29:38.352877+00:00","id":464,"links":{},"metadata":{"_buckets":{"deposit":"74b56621-c4f9-4f4d-add6-d346b55ac2c6"},"_deposit":{"created_by":2,"id":"464","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"464"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00000464","sets":["8:9"]},"author_link":["2435","2431","2430","2423","2427","2436","2426","2433","2428","2425","2422","2429","2432","2434","2424"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-07-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"240","bibliographicPageStart":"232","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"Journal of Diabetes Investigation"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aims/Introduction: The role of glucagon abnormality has recently been reported in type 2 diabetes; however, its role in gestational diabetes mellitus (GDM) is still unknown. The glucose intolerance in GDM is heterogeneous, and not all patients require insulin treatment during pregnancy. Here, we investigated whether glucagon abnormality is associated with the requirement for insulin treatment during pregnancy. Materials and Methods: A total of 49 pregnant women diagnosed with GDM were enrolled. They underwent a 75-g oral glucose tolerance test during mid-gestation, and we measured their plasma glucagon levels (by a new sandwich enzyme-linked immunosorbent assay) at fasting (0 min), and at 30, 60 and 120 min after glucose load in addition to the levels of plasma glucose and serum insulin. All participants underwent another oral glucose tolerance test at postpartum. Results: Of the 49 patients, 15 required insulin treatment (Insulin group) and 34 were treated with diet therapy alone until delivery (Diet group). The early-phase glucagon secretion after glucose load, as determined by the changes in glucagon from the baseline to 30 min, was paradoxically augmented during mid-gestation in the Insulin group, but not in the Diet group. The impaired glucagon suppression during mid-gestation in the Insulin group was not associated with insulin secretory/sensitivity indexes studied, and was ameliorated postpartum, although the plasma glucose levels remained higher in the Insulin group versus the Diet group. Conclusions: Impaired early-phase suppression of glucagon could be associated with the requirement for insulin treatment during pregnancy in patients with GDM.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Journal of Diabetes Investigation, 11(1), pp.232-240; 2020","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"John Wiley & Sons Australia, Ltd"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/jdi.13096","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2019 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2040-1116","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"20401124","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Horie, Ichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Haraguchi, Ai"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ito, Ayako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nozaki, Aya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Natsuda, Shoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Akazawa, Satoru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mori, Yoshitaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ando, Takao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Higashijima, Ai"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hasegawa, Yuri"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshida, Atsushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miura, Kiyonori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Masuzaki, Hideaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawakami, Atsushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Abiru, Norio"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-18"}],"displaytype":"detail","filename":"JDI11_232.pdf","filesize":[{"value":"487.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JDI11_232.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/464/files/JDI11_232.pdf"},"version_id":"278373ad-0351-477a-a2c8-f9fdbf9c9ac7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Gestational diabetes","subitem_subject_scheme":"Other"},{"subitem_subject":"Glucagon","subitem_subject_scheme":"Other"},{"subitem_subject":"Sandwich enzyme-linked immunosorbent assay","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Impaired early-phase suppression of glucagon secretion after glucose load is associated with insulin requirement during pregnancy in gestational diabetes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Impaired early-phase suppression of glucagon secretion after glucose load is associated with insulin requirement during pregnancy in gestational diabetes"}]},"item_type_id":"2","owner":"2","path":["9"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-01-23"},"publish_date":"2020-01-23","publish_status":"0","recid":"464","relation_version_is_last":true,"title":["Impaired early-phase suppression of glucagon secretion after glucose load is associated with insulin requirement during pregnancy in gestational diabetes"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:16:25.384330+00:00"}