{"created":"2023-05-15T16:32:41.801012+00:00","id":4641,"links":{},"metadata":{"_buckets":{"deposit":"61ecd828-085f-41e4-a49b-aa480ac7b9d1"},"_deposit":{"created_by":2,"id":"4641","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"4641"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00004641","sets":["25:26"]},"author_link":["18629","18627","18632","18624","18628","18630","18631","18626","18623","18625"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"1813","bibliographicPageStart":"1805","bibliographicVolumeNumber":"19","bibliographic_titles":[{"bibliographic_title":"Journal of Cellular and Molecular Medicine"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The regenerative potential of cardiosphere-derived cells (CDCs) for ischaemic heart disease has been demonstrated in mice, rats, pigs and a recently completed clinical trial. The regenerative potential of CDCs from dog hearts has yet to be tested. Here, we show that canine CDCs can be produced from adult dog hearts. These cells display similar phenotypes in comparison to previously studied CDCs derived from rodents and human beings. Canine CDCs can differentiate into cardiomyocytes, smooth muscle cells and endothelial cells in vitro. In addition, conditioned media from canine CDCs promote angiogenesis but inhibit cardiomyocyte death. In a doxorubicin-induced mouse model of dilated cardiomyopathy (DCM), intravenous infusion of canine CDCs improves cardiac function and decreases cardiac fibrosis. Histology revealed that injected canine CDCs engraft in the mouse heart and increase capillary density. Out study demonstrates the regenerative potential of canine CDCs in a mouse model of DCM.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Journal of Cellular and Molecular Medicine, 19(8), pp.1805-1813; 2015","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Wiley-Blackwell"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/jcmm.12585","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2015 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine."},{"subitem_rights":"This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited."}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"15821838","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hensley, Michael Taylor"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"de, Andrade  James"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Keene, Bruce"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Meurs, Kathryn"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tang, Junnan"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wang, Zegen"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Caranasos, Thomas G."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Piedrahita, Jorge"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Li, Tao-Sheng"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Cheng, Ke"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"JCMM19_1805.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JCMM19_1805.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/4641/files/JCMM19_1805.pdf"},"version_id":"0f42cfcf-c85d-4809-bff1-a3fca8d0fa16"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Cardiosphere-derived cells","subitem_subject_scheme":"Other"},{"subitem_subject":"Dilated cardiomyopathy","subitem_subject_scheme":"Other"},{"subitem_subject":"Dogs","subitem_subject_scheme":"Other"},{"subitem_subject":"Stem cell therapy","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Cardiac regenerative potential of cardiosphere-derived cells from adult dog hearts","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Cardiac regenerative potential of cardiosphere-derived cells from adult dog hearts"}]},"item_type_id":"2","owner":"2","path":["26"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-08-18"},"publish_date":"2015-08-18","publish_status":"0","recid":"4641","relation_version_is_last":true,"title":["Cardiac regenerative potential of cardiosphere-derived cells from adult dog hearts"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:18:17.857112+00:00"}