{"created":"2023-05-15T16:32:43.526979+00:00","id":4681,"links":{},"metadata":{"_buckets":{"deposit":"88a04a36-c47f-4d8c-8c26-b808e4216e63"},"_deposit":{"created_by":2,"id":"4681","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"4681"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00004681","sets":["27:28"]},"author_link":["18877","18879","18876","18878"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"376","bibliographicPageStart":"370","bibliographicVolumeNumber":"24","bibliographic_titles":[{"bibliographic_title":"Implant Dentistry"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objectives: The aim of this study is to investigate the effect of macroscopic grooves on bone formation in vivo and differentiation of human mesenchymal stem cells (hMSCs) in vitro. Materials and Methods: The effects of macroscopic grooves on titanium alloy implants and disks were tested in rabbit tibiae and cultured hMSCs. The bone-to-implant contact (BIC) and bone area were evaluated in rabbit tibiae at 6 and 24 weeks after implant insertion. Osteoblastic differentiation was assessed by alkaline phosphatase (ALP) activity and real-time reverse-transcription polymerase chain reaction (RT-PCR) on days 7, 14, and 21. All values were statically analyzed. Results: BIC and bone area inside the grooves were significantly higher than those of control implants (P < 0.05). ALP activity was significantly higher for titanium disks with macroscopic grooves than without grooves on day 14 (P < 0.05). Real-time RT-PCR showed that the expression of osteogenic genes was significantly higher for disks with grooves on day 7 (P < 0.01). Conclusions: Macroscopic grooves accelerate osteoblastic differentiation in vitro and stimulate direct bone growth and deposition within the grooves in vivo.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Implant Dentistry, 24(4), pp.370-376; 2015","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Lippincott Williams and Wilkins"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1097/ID.0000000000000257","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2015 Wolters Kluwer Health, Inc."},{"subitem_rights":"This is a non-final version of an article published in final form in Implant Dentistry, 24(4), pp.370-376; 2015"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"10566163","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Miyahara, Kenji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Watamoto, Takao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Uto, Yusuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sawase, Takashi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-21"}],"displaytype":"detail","filename":"ImpDen24_370.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ImpDen24_370.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/4681/files/ImpDen24_370.pdf"},"version_id":"e1febad4-4621-4a90-b868-6df6f1c953e2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"bone formation","subitem_subject_scheme":"Other"},{"subitem_subject":"dental implant","subitem_subject_scheme":"Other"},{"subitem_subject":"human mesenchymal stem cell","subitem_subject_scheme":"Other"},{"subitem_subject":"rabbit tibia","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effect of Macroscopic Grooves on Bone Formation and Osteoblastic Differentiation.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effect of Macroscopic Grooves on Bone Formation and Osteoblastic Differentiation."}]},"item_type_id":"2","owner":"2","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-09-01"},"publish_date":"2016-09-01","publish_status":"0","recid":"4681","relation_version_is_last":true,"title":["Effect of Macroscopic Grooves on Bone Formation and Osteoblastic Differentiation."],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:17:23.531587+00:00"}